DegronMD - Q96JH8(RADIL)

FUNCTION: Downstream effector of Rap required for cell adhesion and migration of neural crest precursors during development. {ECO:0000269|PubMed:17704304}.

GO - Biological processes (BP): neural crest cell migration [GO:0001755]; signal transduction [GO:0007165]; substrate adhesion-dependent cell spreading [GO:0034446]

GO - Molecular function (MF): GTPase binding [GO:0051020]

GO - Cellular component (CC): microtubule [GO:0005874]; protein-containing complex [GO:0032991]

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Degron hit	Class	E3 ligase	Source protein	Location	Detail
LLTPPST	DEG_SCF_FBW7_1	FBXW7	Ras-associating and dilute domain-containing protein	902:908	More..
LLLFKD	LIG_APCC_ABBA_1	APC,CDC20,FZR1	Ras-associating and dilute domain-containing protein	352:357	More..

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R355C	DO9756	COAD	ICGC	LLLFKD	LIG_APCC_ABBA_1	352:357	Mutation altering degron motif	0.8301
p.R355C	DO14252	HNSC	ICGC	LLLFKD	LIG_APCC_ABBA_1	352:357	Mutation altering degron motif	0.8301
p.R355C	DO46327	OV	ICGC	LLLFKD	LIG_APCC_ABBA_1	352:357	Mutation altering degron motif	0.8301
p.R355H	DO51860	BLCA	ICGC	LLLFKD	LIG_APCC_ABBA_1	352:357	Mutation altering degron motif	0.8244
p.R356S	DO24800	LUAD	ICGC	LLLFKD	LIG_APCC_ABBA_1	352:357	Mutation altering degron motif	0.7427
p.D357Y	TCGA-73-A9RS	LUAD	TCGA	LLLFKD	LIG_APCC_ABBA_1	352:357	Mutation altering degron motif	0.7325
p.L903R	ACH-001786	Colon/Colorectal Cancer	CCLE	LLTPPST	DEG_SCF_FBW7_1	902:908	Mutation altering degron motif	0.7316
p.P350T	DO26806	LUSC	ICGC	LLLFKD	LIG_APCC_ABBA_1	352:357	Mutation blocking phosphorylation signal	0.7222
p.S907N	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	LLTPPST	DEG_SCF_FBW7_1	902:908	Mutation altering degron motif	0.5958
p.S907N	ACH-000980	Lung Cancer	CCLE	LLTPPST	DEG_SCF_FBW7_1	902:908	Mutation altering degron motif	0.5958
p.S907N	NCI-H1155	lung	COSMIC	LLTPPST	DEG_SCF_FBW7_1	902:908	Mutation altering degron motif	0.5958
p.P358T	SIDM00750	Non-Small Cell Lung Carcinoma	GDSC	LLLFKD	LIG_APCC_ABBA_1	352:357	Mutation rewiring degron network	0.3056
p.P358T	ACH-000869	Lung Cancer	CCLE	LLLFKD	LIG_APCC_ABBA_1	352:357	Mutation rewiring degron network	0.3056
p.A359G	TCGA-05-4382	LUAD	TCGA	LLLFKD	LIG_APCC_ABBA_1	352:357	Mutation rewiring degron network	0.2778
p.A359V	SIDM00217	Colorectal Carcinoma	GDSC	LLLFKD	LIG_APCC_ABBA_1	352:357	Mutation rewiring degron network	0.2778
p.A359V	ACH-000999	Colon/Colorectal Cancer	CCLE	LLLFKD	LIG_APCC_ABBA_1	352:357	Mutation rewiring degron network	0.2778
p.Q360K	TCGA-05-4410	LUAD	TCGA	LLLFKD	LIG_APCC_ABBA_1	352:357	Mutation rewiring degron network	0.25
p.Q360H	TCGA-90-7769	LUSC	TCGA	LLLFKD	LIG_APCC_ABBA_1	352:357	Mutation rewiring degron network	0.25
p.G911D	TCGA-IB-7651	PAAD	TCGA	LLTPPST	DEG_SCF_FBW7_1	902:908	Mutation rewiring degron network	0.25
p.S899L	SIDM00781	Colorectal Carcinoma	GDSC	LLTPPST	DEG_SCF_FBW7_1	902:908	Mutation rewiring degron network	0.25

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

RADIL

UniProt ID: Q96JH8

Entrez ID: 55698

Protein name: Ras-associating and dilute domain-containing protein

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RADIL in