DegronMD - Q96JH8(RADIL)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A359G	TCGA-05-4382	LUAD	TCGA	LLLFKD	LIG_APCC_ABBA_1	352:357	Mutation rewiring degron network	0.2778
p.Q360K	TCGA-05-4410	LUAD	TCGA	LLLFKD	LIG_APCC_ABBA_1	352:357	Mutation rewiring degron network	0.25
p.D357Y	TCGA-73-A9RS	LUAD	TCGA	LLLFKD	LIG_APCC_ABBA_1	352:357	Mutation altering degron motif	0.7325
p.Q360H	TCGA-90-7769	LUSC	TCGA	LLLFKD	LIG_APCC_ABBA_1	352:357	Mutation rewiring degron network	0.25
p.L347M	TCGA-B5-A5OC	UCEC	TCGA	LLLFKD	LIG_APCC_ABBA_1	352:357	Mutation rewiring degron network	0.1944
p.D898N	TCGA-D3-A2JL	SKCM	TCGA	LLTPPST	DEG_SCF_FBW7_1	902:908	Mutation rewiring degron network	0.2222
p.P363L	TCGA-D6-6516	HNSC	TCGA	LLLFKD	LIG_APCC_ABBA_1	352:357	Mutation rewiring degron network	0.1667
p.P895Q	TCGA-DA-A1I7	SKCM	TCGA	LLTPPST	DEG_SCF_FBW7_1	902:908	Mutation rewiring degron network	0.1389
p.G342V	TCGA-EE-A2GK	SKCM	TCGA	LLLFKD	LIG_APCC_ABBA_1	352:357	Mutation rewiring degron network	0.0556
p.P894L	TCGA-FW-A3R5	SKCM	TCGA	LLTPPST	DEG_SCF_FBW7_1	902:908	Mutation rewiring degron network	0.1111
p.P894L	ACH-002095	Lung Cancer	CCLE	LLTPPST	DEG_SCF_FBW7_1	902:908	Mutation rewiring degron network	0.1111
p.G911D	TCGA-IB-7651	PAAD	TCGA	LLTPPST	DEG_SCF_FBW7_1	902:908	Mutation rewiring degron network	0.25
p.R355H	DO51860	BLCA	ICGC	LLLFKD	LIG_APCC_ABBA_1	352:357	Mutation altering degron motif	0.8244
p.P366R	DO10300	COAD	ICGC	LLLFKD	LIG_APCC_ABBA_1	352:357	Mutation rewiring degron network	0.0833
p.R355C	DO9756	COAD	ICGC	LLLFKD	LIG_APCC_ABBA_1	352:357	Mutation altering degron motif	0.8301
p.R355C	DO14252	HNSC	ICGC	LLLFKD	LIG_APCC_ABBA_1	352:357	Mutation altering degron motif	0.8301
p.R355C	DO46327	OV	ICGC	LLLFKD	LIG_APCC_ABBA_1	352:357	Mutation altering degron motif	0.8301
p.E367K	DO234154	ESAD	ICGC	LLLFKD	LIG_APCC_ABBA_1	352:357	Mutation rewiring degron network	0.0556
p.E367K	DO37474	SKCM	ICGC	LLLFKD	LIG_APCC_ABBA_1	352:357	Mutation rewiring degron network	0.0556
p.P366L	DO50970	LICA	ICGC	LLLFKD	LIG_APCC_ABBA_1	352:357	Mutation rewiring degron network	0.0833
p.R356S	DO24800	LUAD	ICGC	LLLFKD	LIG_APCC_ABBA_1	352:357	Mutation altering degron motif	0.7427
p.P350T	DO26806	LUSC	ICGC	LLLFKD	LIG_APCC_ABBA_1	352:357	Mutation blocking phosphorylation signal	0.7222
p.C348G	DO51256	SKCM	ICGC	LLLFKD	LIG_APCC_ABBA_1	352:357	Mutation rewiring degron network	0.2222
p.P343L	DO47795	STAD	ICGC	LLLFKD	LIG_APCC_ABBA_1	352:357	Mutation rewiring degron network	0.0833
p.P343S	DO229229	THCA	ICGC	LLLFKD	LIG_APCC_ABBA_1	352:357	Mutation rewiring degron network	0.0833
p.E364K	DO41572	UCEC	ICGC	LLLFKD	LIG_APCC_ABBA_1	352:357	Mutation rewiring degron network	0.1389
p.E364K	DO43755	UCEC	ICGC	LLLFKD	LIG_APCC_ABBA_1	352:357	Mutation rewiring degron network	0.1389
p.P912T	SIDM02039	Colorectal Carcinoma	GDSC	LLTPPST	DEG_SCF_FBW7_1	902:908	Mutation rewiring degron network	0.2222
p.S899L	SIDM00781	Colorectal Carcinoma	GDSC	LLTPPST	DEG_SCF_FBW7_1	902:908	Mutation rewiring degron network	0.25
p.S899L	ACH-001199	Colon/Colorectal Cancer	CCLE	LLTPPST	DEG_SCF_FBW7_1	902:908	Mutation rewiring degron network	0.25
p.S899L	SNU-C2B	large intestine	COSMIC	LLTPPST	DEG_SCF_FBW7_1	902:908	Mutation rewiring degron network	0.25
p.P894A	SIDM00343	Glioblastoma	GDSC	LLTPPST	DEG_SCF_FBW7_1	902:908	Mutation rewiring degron network	0.1111
p.P894A	ACH-002268	Brain Cancer	CCLE	LLTPPST	DEG_SCF_FBW7_1	902:908	Mutation rewiring degron network	0.1111
p.P894A	LN-405	central nervous system	COSMIC	LLTPPST	DEG_SCF_FBW7_1	902:908	Mutation rewiring degron network	0.1111
p.S907N	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	LLTPPST	DEG_SCF_FBW7_1	902:908	Mutation altering degron motif	0.5958
p.S907N	ACH-000980	Lung Cancer	CCLE	LLTPPST	DEG_SCF_FBW7_1	902:908	Mutation altering degron motif	0.5958
p.S907N	NCI-H1155	lung	COSMIC	LLTPPST	DEG_SCF_FBW7_1	902:908	Mutation altering degron motif	0.5958
p.A359V	SIDM00217	Colorectal Carcinoma	GDSC	LLLFKD	LIG_APCC_ABBA_1	352:357	Mutation rewiring degron network	0.2778
p.A359V	ACH-000999	Colon/Colorectal Cancer	CCLE	LLLFKD	LIG_APCC_ABBA_1	352:357	Mutation rewiring degron network	0.2778
p.P358T	SIDM00750	Non-Small Cell Lung Carcinoma	GDSC	LLLFKD	LIG_APCC_ABBA_1	352:357	Mutation rewiring degron network	0.3056
p.P358T	ACH-000869	Lung Cancer	CCLE	LLLFKD	LIG_APCC_ABBA_1	352:357	Mutation rewiring degron network	0.3056
p.G342R	SIDM00750	Non-Small Cell Lung Carcinoma	GDSC	LLLFKD	LIG_APCC_ABBA_1	352:357	Mutation rewiring degron network	0.0556
p.G342R	ACH-000869	Lung Cancer	CCLE	LLLFKD	LIG_APCC_ABBA_1	352:357	Mutation rewiring degron network	0.0556
p.G342R	ACH-001610	Brain Cancer	CCLE	LLLFKD	LIG_APCC_ABBA_1	352:357	Mutation rewiring degron network	0.0556
p.G342R	NCI-H1568	lung	COSMIC	LLLFKD	LIG_APCC_ABBA_1	352:357	Mutation rewiring degron network	0.0556
p.L903R	ACH-001786	Colon/Colorectal Cancer	CCLE	LLTPPST	DEG_SCF_FBW7_1	902:908	Mutation altering degron motif	0.7316

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RADIL

UniProt ID: Q96JH8

Entrez ID: 55698

Protein name: Ras-associating and dilute domain-containing protein

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for RADIL in