DegronMD

Uniprot ID: Q96JH8

Source protein: Ras-associating and dilute domain-containing protein

Source gene: RADIL

Class: DEG_SCF_FBW7_1

Location: 902:908

E3 ligase: FBXW7

DEGRON score: 0.9969

ASA_SCORE: 77.4286

COIL: 0.9324

CONS_SCORE: 0.5012

DSS_SCORE: 0.8014

HELIX: 0.0207

FCONS_SCORE: 1.1684

RIG_SCORE: 0.5969

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D898N	TCGA-D3-A2JL	SKCM	TCGA	LLTPPST	DEG_SCF_FBW7_1	0.2222
p.P895Q	TCGA-DA-A1I7	SKCM	TCGA	LLTPPST	DEG_SCF_FBW7_1	0.1389
p.P894L	TCGA-FW-A3R5	SKCM	TCGA	LLTPPST	DEG_SCF_FBW7_1	0.1111
p.P894L	ACH-002095	Lung Cancer	CCLE	LLTPPST	DEG_SCF_FBW7_1	0.1111
p.G911D	TCGA-IB-7651	PAAD	TCGA	LLTPPST	DEG_SCF_FBW7_1	0.25
p.P912T	SIDM02039	Colorectal Carcinoma	GDSC	LLTPPST	DEG_SCF_FBW7_1	0.2222
p.S899L	SIDM00781	Colorectal Carcinoma	GDSC	LLTPPST	DEG_SCF_FBW7_1	0.25
p.S899L	ACH-001199	Colon/Colorectal Cancer	CCLE	LLTPPST	DEG_SCF_FBW7_1	0.25
p.S899L	SNU-C2B	large_intestine	COSMIC	LLTPPST	DEG_SCF_FBW7_1	0.25
p.P894A	SIDM00343	Glioblastoma	GDSC	LLTPPST	DEG_SCF_FBW7_1	0.1111
p.P894A	ACH-002268	Brain Cancer	CCLE	LLTPPST	DEG_SCF_FBW7_1	0.1111
p.P894A	LN-405	central_nervous_system	COSMIC	LLTPPST	DEG_SCF_FBW7_1	0.1111
p.S907N	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	LLTPPST	DEG_SCF_FBW7_1	0.5958
p.S907N	ACH-000980	Lung Cancer	CCLE	LLTPPST	DEG_SCF_FBW7_1	0.5958
p.S907N	NCI-H1155	lung	COSMIC	LLTPPST	DEG_SCF_FBW7_1	0.5958
p.L903R	ACH-001786	Colon/Colorectal Cancer	CCLE	LLTPPST	DEG_SCF_FBW7_1	0.7316

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96JH8	Ras-associating and dilute domain-containing protein	DEG_SCF_FBW7_1	902:908	LLTPPST	FBXW7	0.9969	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons