DegronMD

Uniprot ID: Q96JH8

Source protein: Ras-associating and dilute domain-containing protein

Source gene: RADIL

Class: LIG_APCC_ABBA_1

Location: 352:357

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7772

ASA_SCORE: 28.35

COIL: 0.2288

CONS_SCORE: 0.7421

DSS_SCORE: 0.0171

HELIX: 0.2683

FCONS_SCORE: 1.2501

RIG_SCORE: 0.9328

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A359G	TCGA-05-4382	LUAD	TCGA	LLLFKD	LIG_APCC_ABBA_1	0.2778
p.Q360K	TCGA-05-4410	LUAD	TCGA	LLLFKD	LIG_APCC_ABBA_1	0.25
p.D357Y	TCGA-73-A9RS	LUAD	TCGA	LLLFKD	LIG_APCC_ABBA_1	0.7325
p.Q360H	TCGA-90-7769	LUSC	TCGA	LLLFKD	LIG_APCC_ABBA_1	0.25
p.L347M	TCGA-B5-A5OC	UCEC	TCGA	LLLFKD	LIG_APCC_ABBA_1	0.1944
p.P363L	TCGA-D6-6516	HNSC	TCGA	LLLFKD	LIG_APCC_ABBA_1	0.1667
p.G342V	TCGA-EE-A2GK	SKCM	TCGA	LLLFKD	LIG_APCC_ABBA_1	0.0556
p.R355H	DO51860	BLCA	ICGC	LLLFKD	LIG_APCC_ABBA_1	0.8244
p.P366R	DO10300	COAD	ICGC	LLLFKD	LIG_APCC_ABBA_1	0.0833
p.R355C	DO9756	COAD	ICGC	LLLFKD	LIG_APCC_ABBA_1	0.8301
p.R355C	DO14252	HNSC	ICGC	LLLFKD	LIG_APCC_ABBA_1	0.8301
p.R355C	DO46327	OV	ICGC	LLLFKD	LIG_APCC_ABBA_1	0.8301
p.E367K	DO234154	ESAD	ICGC	LLLFKD	LIG_APCC_ABBA_1	0.0556
p.E367K	DO37474	SKCM	ICGC	LLLFKD	LIG_APCC_ABBA_1	0.0556
p.P366L	DO50970	LICA	ICGC	LLLFKD	LIG_APCC_ABBA_1	0.0833
p.R356S	DO24800	LUAD	ICGC	LLLFKD	LIG_APCC_ABBA_1	0.7427
p.P350T	DO26806	LUSC	ICGC	LLLFKD	LIG_APCC_ABBA_1	0.7222
p.C348G	DO51256	SKCM	ICGC	LLLFKD	LIG_APCC_ABBA_1	0.2222
p.P343L	DO47795	STAD	ICGC	LLLFKD	LIG_APCC_ABBA_1	0.0833
p.P343S	DO229229	THCA	ICGC	LLLFKD	LIG_APCC_ABBA_1	0.0833
p.E364K	DO41572	UCEC	ICGC	LLLFKD	LIG_APCC_ABBA_1	0.1389
p.E364K	DO43755	UCEC	ICGC	LLLFKD	LIG_APCC_ABBA_1	0.1389
p.A359V	SIDM00217	Colorectal Carcinoma	GDSC	LLLFKD	LIG_APCC_ABBA_1	0.2778
p.A359V	ACH-000999	Colon/Colorectal Cancer	CCLE	LLLFKD	LIG_APCC_ABBA_1	0.2778
p.P358T	SIDM00750	Non-Small Cell Lung Carcinoma	GDSC	LLLFKD	LIG_APCC_ABBA_1	0.3056
p.P358T	ACH-000869	Lung Cancer	CCLE	LLLFKD	LIG_APCC_ABBA_1	0.3056
p.G342R	SIDM00750	Non-Small Cell Lung Carcinoma	GDSC	LLLFKD	LIG_APCC_ABBA_1	0.0556
p.G342R	ACH-000869	Lung Cancer	CCLE	LLLFKD	LIG_APCC_ABBA_1	0.0556
p.G342R	ACH-001610	Brain Cancer	CCLE	LLLFKD	LIG_APCC_ABBA_1	0.0556
p.G342R	NCI-H1568	lung	COSMIC	LLLFKD	LIG_APCC_ABBA_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96JH8	Ras-associating and dilute domain-containing protein	LIG_APCC_ABBA_1	352:357	LLLFKD	APC,CDC20,FZR1	0.7772	More...
Q9HAW4	Claspin	LIG_APCC_ABBA_1	725:730	LLLFKD	APC,CDC20,FZR1	0.9862	More...
Q9Y3C4	EKC/KEOPS complex subunit TPRKB	LIG_APCC_ABBA_1	17:22	LLLFKD	APC,CDC20,FZR1	0.6529	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LLLFKD

Degron related mutations and impact score

Drug responses associated with RADIL mutations

All proteins holding degron of LLLFKD