DegronMD

Uniprot ID: Q9HAW4

Source protein: Claspin

Source gene: CLSPN

Class: DEG_SCF_TRCP1_1

Location: 29:34

E3 ligase: BTRC

DEGRON score: 0.9986

ASA_SCORE: 71.4833

COIL: 0.8683

CONS_SCORE: 0.3513

DSS_SCORE: 0.7658

HELIX: 0.0872

FCONS_SCORE: 1.1383

RIG_SCORE: 0.5436

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A24T	TCGA-B5-A0JY	UCEC	TCGA	DSGQGS	DEG_SCF_TRCP1_1	0.1944
p.A24T	DO43041	UCEC	ICGC	DSGQGS	DEG_SCF_TRCP1_1	0.1944
p.D25E	TCGA-BP-4964	KIRC	TCGA	DSGQGS	DEG_SCF_TRCP1_1	0.2222
p.D25E	DO16263	KIRC	ICGC	DSGQGS	DEG_SCF_TRCP1_1	0.2222
p.P27L	TCGA-EE-A181	SKCM	TCGA	DSGQGS	DEG_SCF_TRCP1_1	0.2778
p.P27L	DO37444	SKCM	ICGC	DSGQGS	DEG_SCF_TRCP1_1	0.2778
p.L41F	DO225215	BRCA	ICGC	DSGQGS	DEG_SCF_TRCP1_1	0.1389
p.L41F	DO227836	BRCA	ICGC	DSGQGS	DEG_SCF_TRCP1_1	0.1389
p.I19V	SIDM00451	T-Lymphoblastic Leukemia	GDSC	DSGQGS	DEG_SCF_TRCP1_1	0.0556
p.I19V	ACH-000937	Leukemia	CCLE	DSGQGS	DEG_SCF_TRCP1_1	0.0556
p.I19V	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	DSGQGS	DEG_SCF_TRCP1_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q16281	Cyclic nucleotide-gated cation channel alpha-3	DEG_SCF_TRCP1_1	59:64	DSGQGS	BTRC	0.9061	More...
Q9HAW4	Claspin	DEG_SCF_TRCP1_1	29:34	DSGQGS	BTRC	0.9986	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons