FUNCTION: Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of cone photoreceptors. Induced a flickering channel gating...
FUNCTION: Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of cone photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGB3 (By similarity). Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones. {ECO:0000250, ECO:0000269|PubMed:10888875}.
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GO - Biological processes (BP):
cation transport [GO:0006812]; inorganic cation import across plasma membrane [GO:0098659]; response to cAMP [GO:0051591]; response to corticosteroid [GO:0031960]; response to magnesium ion [GO:0032026]; signal transduction [GO:0007165]; visual perception [GO:0007601]...
cation transport [GO:0006812]; inorganic cation import across plasma membrane [GO:0098659]; response to cAMP [GO:0051591]; response to corticosteroid [GO:0031960]; response to magnesium ion [GO:0032026]; signal transduction [GO:0007165]; visual perception [GO:0007601]
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GO - Molecular function (MF):
cGMP binding [GO:0030553]; intracellular cAMP-activated cation channel activity [GO:0005222]; intracellular cGMP-activated cation channel activity [GO:0005223]; ligand-gated ion channel activity [GO:0015276]; protein C-terminus binding [GO:0008022]...
cGMP binding [GO:0030553]; intracellular cAMP-activated cation channel activity [GO:0005222]; intracellular cGMP-activated cation channel activity [GO:0005223]; ligand-gated ion channel activity [GO:0015276]; protein C-terminus binding [GO:0008022]
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GO - Cellular component (CC):
axon initial segment [GO:0043194]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; glial cell projection [GO:0097386]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; transmembrane transporter complex [GO:1902495]...
axon initial segment [GO:0043194]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; glial cell projection [GO:0097386]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; transmembrane transporter complex [GO:1902495]
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