DegronMD

Uniprot ID: Q16281

Source protein: Cyclic nucleotide-gated cation channel alpha-3

Source gene: CNGA3

Class: DEG_SCF_TRCP1_1

Location: 59:64

E3 ligase: BTRC

DEGRON score: 0.9061

ASA_SCORE: 74.2

COIL: 0.87

CONS_SCORE: 0.3527

DSS_SCORE: 0.4469

HELIX: 0.0912

FCONS_SCORE: 0.8833

RIG_SCORE: 0.6725

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S74P	TCGA-05-4382	LUAD	TCGA	DSGQGS	DEG_SCF_TRCP1_1	0.0556
p.S74P	DO24900	LUAD	ICGC	DSGQGS	DEG_SCF_TRCP1_1	0.0556
p.A58S	TCGA-24-1431	OV	TCGA	DSGQGS	DEG_SCF_TRCP1_1	0.3056
p.A58S	DO32307	OV	ICGC	DSGQGS	DEG_SCF_TRCP1_1	0.3056
p.A51T	TCGA-BR-4201	STAD	TCGA	DSGQGS	DEG_SCF_TRCP1_1	0.1111
p.A51T	TCGA-BR-4361	STAD	TCGA	DSGQGS	DEG_SCF_TRCP1_1	0.1111
p.A51T	DO38887	STAD	ICGC	DSGQGS	DEG_SCF_TRCP1_1	0.1111
p.A51T	DO38707	STAD	ICGC	DSGQGS	DEG_SCF_TRCP1_1	0.1111
p.S74L	TCGA-D1-A103	UCEC	TCGA	DSGQGS	DEG_SCF_TRCP1_1	0.0556
p.S74L	TCGA-EB-A3Y7	SKCM	TCGA	DSGQGS	DEG_SCF_TRCP1_1	0.0556
p.S74L	DO37499	SKCM	ICGC	DSGQGS	DEG_SCF_TRCP1_1	0.0556
p.S74L	DO42312	UCEC	ICGC	DSGQGS	DEG_SCF_TRCP1_1	0.0556
p.E53K	TCGA-EE-A29D	SKCM	TCGA	DSGQGS	DEG_SCF_TRCP1_1	0.1667
p.E53K	DO38123	SKCM	ICGC	DSGQGS	DEG_SCF_TRCP1_1	0.1667
p.G67V	TCGA-UB-A7MB	LIHC	TCGA	DSGQGS	DEG_SCF_TRCP1_1	0.25
p.G67V	DO52318	LIHC	ICGC	DSGQGS	DEG_SCF_TRCP1_1	0.25
p.A62D	DO49929	CESC	ICGC	DSGQGS	DEG_SCF_TRCP1_1	0.7793
p.Q68R	DO227987	COCA	ICGC	DSGQGS	DEG_SCF_TRCP1_1	0.2222
p.M61I	DO229010	COCA	ICGC	DSGQGS	DEG_SCF_TRCP1_1	0.7618
p.M61I	DO229013	COCA	ICGC	DSGQGS	DEG_SCF_TRCP1_1	0.7618
p.M61I	DO229016	COCA	ICGC	DSGQGS	DEG_SCF_TRCP1_1	0.7618
p.M61I	DO229003	COCA	ICGC	DSGQGS	DEG_SCF_TRCP1_1	0.7618
p.M61I	DO229346	LAML	ICGC	DSGQGS	DEG_SCF_TRCP1_1	0.7618
p.G69R	DO220885	MELA	ICGC	DSGQGS	DEG_SCF_TRCP1_1	0.1944
p.G69R	DO229240	THCA	ICGC	DSGQGS	DEG_SCF_TRCP1_1	0.1944
p.G68E	DO220885	MELA	ICGC	DSGQGS	DEG_SCF_TRCP1_1	0.2222
p.A51V	DO222908	MELA	ICGC	DSGQGS	DEG_SCF_TRCP1_1	0.1111
p.M52I	DO229240	THCA	ICGC	DSGQGS	DEG_SCF_TRCP1_1	0.1389
p.T54A	SIDM00901	Endometrial Carcinoma	GDSC	DSGQGS	DEG_SCF_TRCP1_1	0.1944
p.T54A	ACH-000940	Endometrial/Uterine Cancer	CCLE	DSGQGS	DEG_SCF_TRCP1_1	0.1944
p.T54A	AN3-CA	endometrium	COSMIC	DSGQGS	DEG_SCF_TRCP1_1	0.1944
p.S70L	HT-115	large_intestine	COSMIC	DSGQGS	DEG_SCF_TRCP1_1	0.1667
p.S70L	ML-1	thyroid	COSMIC	DSGQGS	DEG_SCF_TRCP1_1	0.1667
p.A64T	CFPAC-1	pancreas	COSMIC	DSGQGS	DEG_SCF_TRCP1_1	0.7139
p.A64T	NCI-H1838	lung	COSMIC	DSGQGS	DEG_SCF_TRCP1_1	0.7139
p.S70T	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	DSGQGS	DEG_SCF_TRCP1_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q16281	Cyclic nucleotide-gated cation channel alpha-3	DEG_SCF_TRCP1_1	59:64	DSGQGS	BTRC	0.9061	More...
Q9HAW4	Claspin	DEG_SCF_TRCP1_1	29:34	DSGQGS	BTRC	0.9986	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSGQGS

Degron related mutations and impact score

Drug responses associated with CNGA3 mutations

All proteins holding degron of DSGQGS