DegronMD

Uniprot ID: Q9UQ84

Source protein: Exonuclease 1

Source gene: EXO1

Class: DEG_APCC_KENBOX_2

Location: 390:394

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9695

ASA_SCORE: 95.46

COIL: 0.8396

CONS_SCORE: 0.4512

DSS_SCORE: 0.5679

HELIX: 0.078

FCONS_SCORE: 1.0046

RIG_SCORE: 0.6598

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G382C	TCGA-93-8067	LUAD	TCGA	LKENP	DEG_APCC_KENBOX_2	0.1111
p.G382C	TCGA-FS-A1ZJ	SKCM	TCGA	LKENP	DEG_APCC_KENBOX_2	0.1111
p.G382C	DO25113	LUAD	ICGC	LKENP	DEG_APCC_KENBOX_2	0.1111
p.G382C	DO37956	SKCM	ICGC	LKENP	DEG_APCC_KENBOX_2	0.1111
p.L390V	TCGA-AN-A04D	BRCA	TCGA	LKENP	DEG_APCC_KENBOX_2	0.5654
p.L390V	DO2222	BRCA	ICGC	LKENP	DEG_APCC_KENBOX_2	0.5654
p.R401L	TCGA-DA-A1HV	SKCM	TCGA	LKENP	DEG_APCC_KENBOX_2	0.1389
p.R401L	DO37659	SKCM	ICGC	LKENP	DEG_APCC_KENBOX_2	0.1389
p.T383N	TCGA-EE-A20F	SKCM	TCGA	LKENP	DEG_APCC_KENBOX_2	0.1389
p.T383N	DO37961	SKCM	ICGC	LKENP	DEG_APCC_KENBOX_2	0.1389
p.E380Q	SIDM00134	Non-Small Cell Lung Carcinoma	GDSC	LKENP	DEG_APCC_KENBOX_2	0.0556
p.E380Q	ACH-000825	Lung Cancer	CCLE	LKENP	DEG_APCC_KENBOX_2	0.0556
p.E380Q	HOP-92	lung	COSMIC	LKENP	DEG_APCC_KENBOX_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IVW4	Cyclin-dependent kinase-like 3	DEG_APCC_KENBOX_2	418:422	LKENP	APC,CDC20,FZR1	0.6018	More...
Q8TAM6	Ermin	DEG_APCC_KENBOX_2	79:83	LKENP	APC,CDC20,FZR1	0.9084	More...
Q96SB4	SRSF protein kinase 1	DEG_APCC_KENBOX_2	317:321	LKENP	APC,CDC20,FZR1	0.8488	More...
Q9BSI4	TERF1-interacting nuclear factor 2	DEG_APCC_KENBOX_2	340:344	LKENP	APC,CDC20,FZR1	0.8292	More...
Q9UQ84	Exonuclease 1	DEG_APCC_KENBOX_2	390:394	LKENP	APC,CDC20,FZR1	0.9695	More...
Q9H6X5	Uncharacterized protein C19orf44	DEG_APCC_KENBOX_2	64:68	LKENP	APC,CDC20,FZR1	0.5525	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons