DegronMD

Uniprot ID: Q9H6X5

Source protein: Uncharacterized protein C19orf44

Source gene: C19orf44

Class: DEG_APCC_KENBOX_2

Location: 64:68

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5525

ASA_SCORE: 111.12

COIL: 0.842

CONS_SCORE: 0.3093

DSS_SCORE: 0.4496

HELIX: 0.0964

FCONS_SCORE: 0.9977

RIG_SCORE: 0.7634

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G71W	TCGA-17-Z015	LUAD	TCGA	LKENP	DEG_APCC_KENBOX_2	0.25
p.K65Q	TCGA-A2-A0SV	BRCA	TCGA	LKENP	DEG_APCC_KENBOX_2	0.6944
p.K65Q	DO1914	BRCA	ICGC	LKENP	DEG_APCC_KENBOX_2	0.6944
p.L64M	TCGA-J9-A8CN	PRAD	TCGA	LKENP	DEG_APCC_KENBOX_2	0.5999
p.L64M	DO219269	PRAD	ICGC	LKENP	DEG_APCC_KENBOX_2	0.5999
p.G71R	TCGA-OR-A5J5	ACC	TCGA	LKENP	DEG_APCC_KENBOX_2	0.25
p.G71R	DO10970	GBM	ICGC	LKENP	DEG_APCC_KENBOX_2	0.25
p.L57V	DO227535	BRCA	ICGC	LKENP	DEG_APCC_KENBOX_2	0.1389
p.P68T	DO227985	COCA	ICGC	LKENP	DEG_APCC_KENBOX_2	0.5919
p.E66K	DO220900	MELA	ICGC	LKENP	DEG_APCC_KENBOX_2	0.7022
p.P68H	SIDM00014	Colorectal Carcinoma	GDSC	LKENP	DEG_APCC_KENBOX_2	0.6583

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IVW4	Cyclin-dependent kinase-like 3	DEG_APCC_KENBOX_2	418:422	LKENP	APC,CDC20,FZR1	0.6018	More...
Q8TAM6	Ermin	DEG_APCC_KENBOX_2	79:83	LKENP	APC,CDC20,FZR1	0.9084	More...
Q96SB4	SRSF protein kinase 1	DEG_APCC_KENBOX_2	317:321	LKENP	APC,CDC20,FZR1	0.8488	More...
Q9BSI4	TERF1-interacting nuclear factor 2	DEG_APCC_KENBOX_2	340:344	LKENP	APC,CDC20,FZR1	0.8292	More...
Q9UQ84	Exonuclease 1	DEG_APCC_KENBOX_2	390:394	LKENP	APC,CDC20,FZR1	0.9695	More...
Q9H6X5	Uncharacterized protein C19orf44	DEG_APCC_KENBOX_2	64:68	LKENP	APC,CDC20,FZR1	0.5525	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons