DegronMD - Q9BSI4(TINF2)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L340M	TCGA-AX-A2HC	UCEC	TCGA	LKENP	DEG_APCC_KENBOX_2	340:344	Mutation altering degron motif	0.5999
p.L340M	DO41572	UCEC	ICGC	LKENP	DEG_APCC_KENBOX_2	340:344	Mutation altering degron motif	0.5999
p.K353Q	DO50857	LIRI	ICGC	LKENP	DEG_APCC_KENBOX_2	340:344	Mutation substituting flanking lysine	0.1944
p.P348S	SIDM00967	Ovarian Carcinoma	GDSC	LKENP	DEG_APCC_KENBOX_2	340:344	Mutation rewiring degron network	0.2222
p.P348S	ACH-002181	Ovarian Cancer	CCLE	LKENP	DEG_APCC_KENBOX_2	340:344	Mutation rewiring degron network	0.2222
p.P348S	OVCA420	ovary	COSMIC	LKENP	DEG_APCC_KENBOX_2	340:344	Mutation rewiring degron network	0.2222
p.L331V	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	LKENP	DEG_APCC_KENBOX_2	340:344	Mutation rewiring degron network	0.0833

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons