DegronMD

Uniprot ID: Q9BSI4

Source protein: TERF1-interacting nuclear factor 2

Source gene: TINF2

Class: DEG_APCC_KENBOX_2

Location: 340:344

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8292

ASA_SCORE: 101.5

COIL: 0.8286

CONS_SCORE: 0.5816

DSS_SCORE: 0.4925

HELIX: 0.106

FCONS_SCORE: 1.0048

RIG_SCORE: 0.7064

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L340M	TCGA-AX-A2HC	UCEC	TCGA	LKENP	DEG_APCC_KENBOX_2	0.5999
p.L340M	DO41572	UCEC	ICGC	LKENP	DEG_APCC_KENBOX_2	0.5999
p.K353Q	DO50857	LIRI	ICGC	LKENP	DEG_APCC_KENBOX_2	0.1944
p.P348S	SIDM00967	Ovarian Carcinoma	GDSC	LKENP	DEG_APCC_KENBOX_2	0.2222
p.P348S	ACH-002181	Ovarian Cancer	CCLE	LKENP	DEG_APCC_KENBOX_2	0.2222
p.P348S	OVCA420	ovary	COSMIC	LKENP	DEG_APCC_KENBOX_2	0.2222
p.L331V	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	LKENP	DEG_APCC_KENBOX_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IVW4	Cyclin-dependent kinase-like 3	DEG_APCC_KENBOX_2	418:422	LKENP	APC,CDC20,FZR1	0.6018	More...
Q8TAM6	Ermin	DEG_APCC_KENBOX_2	79:83	LKENP	APC,CDC20,FZR1	0.9084	More...
Q96SB4	SRSF protein kinase 1	DEG_APCC_KENBOX_2	317:321	LKENP	APC,CDC20,FZR1	0.8488	More...
Q9BSI4	TERF1-interacting nuclear factor 2	DEG_APCC_KENBOX_2	340:344	LKENP	APC,CDC20,FZR1	0.8292	More...
Q9UQ84	Exonuclease 1	DEG_APCC_KENBOX_2	390:394	LKENP	APC,CDC20,FZR1	0.9695	More...
Q9H6X5	Uncharacterized protein C19orf44	DEG_APCC_KENBOX_2	64:68	LKENP	APC,CDC20,FZR1	0.5525	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons