DegronMD - Q9H6X5(C19orf44)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G71W	TCGA-17-Z015	LUAD	TCGA	LKENP	DEG_APCC_KENBOX_2	64:68	Mutation rewiring degron network	0.25
p.K65Q	TCGA-A2-A0SV	BRCA	TCGA	LKENP	DEG_APCC_KENBOX_2	64:68	Mutation altering degron motif	0.6944
p.K65Q	DO1914	BRCA	ICGC	LKENP	DEG_APCC_KENBOX_2	64:68	Mutation altering degron motif	0.6944
p.L64M	TCGA-J9-A8CN	PRAD	TCGA	LKENP	DEG_APCC_KENBOX_2	64:68	Mutation altering degron motif	0.5999
p.L64M	DO219269	PRAD	ICGC	LKENP	DEG_APCC_KENBOX_2	64:68	Mutation altering degron motif	0.5999
p.G71R	TCGA-OR-A5J5	ACC	TCGA	LKENP	DEG_APCC_KENBOX_2	64:68	Mutation rewiring degron network	0.25
p.G71R	DO10970	GBM	ICGC	LKENP	DEG_APCC_KENBOX_2	64:68	Mutation rewiring degron network	0.25
p.L57V	DO227535	BRCA	ICGC	LKENP	DEG_APCC_KENBOX_2	64:68	Mutation rewiring degron network	0.1389
p.P68T	DO227985	COCA	ICGC	LKENP	DEG_APCC_KENBOX_2	64:68	Mutation altering degron motif	0.5919
p.E66K	DO220900	MELA	ICGC	LKENP	DEG_APCC_KENBOX_2	64:68	Mutation altering degron motif	0.7022
p.P68H	SIDM00014	Colorectal Carcinoma	GDSC	LKENP	DEG_APCC_KENBOX_2	64:68	Mutation altering degron motif	0.6583

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons