DegronMD

Uniprot ID: Q8TAM6

Source protein: Ermin

Source gene: ERMN

Class: DEG_APCC_KENBOX_2

Location: 79:83

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9084

ASA_SCORE: 103.18

COIL: 0.6376

CONS_SCORE: 0.6001

DSS_SCORE: 0.4256

HELIX: 0.355

FCONS_SCORE: 1.3567

RIG_SCORE: 0.719

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R74I	TCGA-06-5416	GBM	TCGA	LKENP	DEG_APCC_KENBOX_2	0.1944
p.E85Q	DO49795	BLCA	ICGC	LKENP	DEG_APCC_KENBOX_2	0.2778
p.D86N	DO7977	COAD	ICGC	LKENP	DEG_APCC_KENBOX_2	0.3611
p.N90D	DO234222	ESAD	ICGC	LKENP	DEG_APCC_KENBOX_2	0.1389
p.D93G	DO14974	HNSC	ICGC	LKENP	DEG_APCC_KENBOX_2	0.0556
p.D70N	DO19078	KIRC	ICGC	LKENP	DEG_APCC_KENBOX_2	0.0833
p.L87I	DO228974	LICA	ICGC	LKENP	DEG_APCC_KENBOX_2	0.2222
p.E78K	DO220877	MELA	ICGC	LKENP	DEG_APCC_KENBOX_2	0.3056
p.N87D	DO42384	UCEC	ICGC	LKENP	DEG_APCC_KENBOX_2	0.2222
p.H91N	DO43186	UCEC	ICGC	LKENP	DEG_APCC_KENBOX_2	0.1111
p.C88Y	DO41752	UCEC	ICGC	LKENP	DEG_APCC_KENBOX_2	0.1944
p.K86T	DO43755	UCEC	ICGC	LKENP	DEG_APCC_KENBOX_2	0.3611
p.E88K	SIDM00671	T-Cell Non-Hodgkin's Lymphoma	GDSC	LKENP	DEG_APCC_KENBOX_2	0.1944
p.E88K	HH	haematopoietic_and_lymphoid_tissue	COSMIC	LKENP	DEG_APCC_KENBOX_2	0.1944
p.M91I	SIDM01145	Gastric Carcinoma	GDSC	LKENP	DEG_APCC_KENBOX_2	0.1111
p.M91I	NCI-SNU-16	stomach	COSMIC	LKENP	DEG_APCC_KENBOX_2	0.1111
p.E75K	ACH-000061	Lymphoma	CCLE	LKENP	DEG_APCC_KENBOX_2	0.2222
p.E75K	HH	haematopoietic_and_lymphoid_tissue	COSMIC	LKENP	DEG_APCC_KENBOX_2	0.2222
p.M78I	ACH-000581	Gastric Cancer	CCLE	LKENP	DEG_APCC_KENBOX_2	0.3056
p.M78I	NCI-SNU-16	stomach	COSMIC	LKENP	DEG_APCC_KENBOX_2	0.3056
p.R90G	NCI-H1963	lung	COSMIC	LKENP	DEG_APCC_KENBOX_2	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IVW4	Cyclin-dependent kinase-like 3	DEG_APCC_KENBOX_2	418:422	LKENP	APC,CDC20,FZR1	0.6018	More...
Q8TAM6	Ermin	DEG_APCC_KENBOX_2	79:83	LKENP	APC,CDC20,FZR1	0.9084	More...
Q96SB4	SRSF protein kinase 1	DEG_APCC_KENBOX_2	317:321	LKENP	APC,CDC20,FZR1	0.8488	More...
Q9BSI4	TERF1-interacting nuclear factor 2	DEG_APCC_KENBOX_2	340:344	LKENP	APC,CDC20,FZR1	0.8292	More...
Q9UQ84	Exonuclease 1	DEG_APCC_KENBOX_2	390:394	LKENP	APC,CDC20,FZR1	0.9695	More...
Q9H6X5	Uncharacterized protein C19orf44	DEG_APCC_KENBOX_2	64:68	LKENP	APC,CDC20,FZR1	0.5525	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons