DegronMD - Q8TAM6(ERMN)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R74I	TCGA-06-5416	GBM	TCGA	LKENP	DEG_APCC_KENBOX_2	79:83	Mutation rewiring degron network	0.1944
p.E85Q	DO49795	BLCA	ICGC	LKENP	DEG_APCC_KENBOX_2	79:83	Mutation rewiring degron network	0.2778
p.D86N	DO7977	COAD	ICGC	LKENP	DEG_APCC_KENBOX_2	79:83	Mutation substituting flanking lysine	0.3611
p.N90D	DO234222	ESAD	ICGC	LKENP	DEG_APCC_KENBOX_2	79:83	Mutation rewiring degron network	0.1389
p.D93G	DO14974	HNSC	ICGC	LKENP	DEG_APCC_KENBOX_2	79:83	Mutation rewiring degron network	0.0556
p.D70N	DO19078	KIRC	ICGC	LKENP	DEG_APCC_KENBOX_2	79:83	Mutation rewiring degron network	0.0833
p.L87I	DO228974	LICA	ICGC	LKENP	DEG_APCC_KENBOX_2	79:83	Mutation rewiring degron network	0.2222
p.E78K	DO220877	MELA	ICGC	LKENP	DEG_APCC_KENBOX_2	79:83	Mutation rewiring degron network	0.3056
p.N87D	DO42384	UCEC	ICGC	LKENP	DEG_APCC_KENBOX_2	79:83	Mutation rewiring degron network	0.2222
p.H91N	DO43186	UCEC	ICGC	LKENP	DEG_APCC_KENBOX_2	79:83	Mutation rewiring degron network	0.1111
p.C88Y	DO41752	UCEC	ICGC	LKENP	DEG_APCC_KENBOX_2	79:83	Mutation rewiring degron network	0.1944
p.K86T	DO43755	UCEC	ICGC	LKENP	DEG_APCC_KENBOX_2	79:83	Mutation substituting flanking lysine	0.3611
p.E88K	SIDM00671	T-Cell Non-Hodgkin's Lymphoma	GDSC	LKENP	DEG_APCC_KENBOX_2	79:83	Mutation rewiring degron network	0.1944
p.E88K	HH	haematopoietic and lymphoid tissue	COSMIC	LKENP	DEG_APCC_KENBOX_2	79:83	Mutation rewiring degron network	0.1944
p.M91I	SIDM01145	Gastric Carcinoma	GDSC	LKENP	DEG_APCC_KENBOX_2	79:83	Mutation rewiring degron network	0.1111
p.M91I	NCI-SNU-16	stomach	COSMIC	LKENP	DEG_APCC_KENBOX_2	79:83	Mutation rewiring degron network	0.1111
p.E75K	ACH-000061	Lymphoma	CCLE	LKENP	DEG_APCC_KENBOX_2	79:83	Mutation rewiring degron network	0.2222
p.E75K	HH	haematopoietic and lymphoid tissue	COSMIC	LKENP	DEG_APCC_KENBOX_2	79:83	Mutation rewiring degron network	0.2222
p.M78I	ACH-000581	Gastric Cancer	CCLE	LKENP	DEG_APCC_KENBOX_2	79:83	Mutation rewiring degron network	0.3056
p.M78I	NCI-SNU-16	stomach	COSMIC	LKENP	DEG_APCC_KENBOX_2	79:83	Mutation rewiring degron network	0.3056
p.R90G	NCI-H1963	lung	COSMIC	LKENP	DEG_APCC_KENBOX_2	79:83	Mutation rewiring degron network	0.1389

Kaplan plot for ERMN in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ERMN

UniProt ID: Q8TAM6

Entrez ID: 57471

Protein name: Ermin (Juxtanodin) (JN)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ERMN in