DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
LKENP
Uniprot ID:
Q8IVW4
Source protein:
Cyclin-dependent kinase-like 3
Source gene:
CDKL3
Class:
DEG_APCC_KENBOX_2
Location:
418:422
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.6018
ASA_SCORE:
96.14
COIL:
0.9146
CONS_SCORE:
0.4207
DSS_SCORE:
0.5059
HELIX:
0.0348
FCONS_SCORE:
1.0433
RIG_SCORE:
0.6596
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.T413A
TCGA-56-8305
LUSC
TCGA
LKENP
DEG_APCC_KENBOX_2
0.1944
p.P411L
TCGA-90-A4ED
LUSC
TCGA
LKENP
DEG_APCC_KENBOX_2
0.1389
p.N410H
TCGA-BH-A18J
BRCA
TCGA
LKENP
DEG_APCC_KENBOX_2
0.1111
p.G417C
TCGA-D7-A6EY
STAD
TCGA
LKENP
DEG_APCC_KENBOX_2
0.3056
p.L418F
TCGA-F4-6856
COAD
TCGA
LKENP
DEG_APCC_KENBOX_2
0.587
p.L415V
DO42961
UCEC
ICGC
LKENP
DEG_APCC_KENBOX_2
0.25
p.L415V
DO41349
UCEC
ICGC
LKENP
DEG_APCC_KENBOX_2
0.25
Drug responses associated with CDKL3 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LKENP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8IVW4
Cyclin-dependent kinase-like 3
DEG_APCC_KENBOX_2
418:422
LKENP
APC,CDC20,FZR1
0.6018
More...
Q8TAM6
Ermin
DEG_APCC_KENBOX_2
79:83
LKENP
APC,CDC20,FZR1
0.9084
More...
Q96SB4
SRSF protein kinase 1
DEG_APCC_KENBOX_2
317:321
LKENP
APC,CDC20,FZR1
0.8488
More...
Q9BSI4
TERF1-interacting nuclear factor 2
DEG_APCC_KENBOX_2
340:344
LKENP
APC,CDC20,FZR1
0.8292
More...
Q9UQ84
Exonuclease 1
DEG_APCC_KENBOX_2
390:394
LKENP
APC,CDC20,FZR1
0.9695
More...
Q9H6X5
Uncharacterized protein C19orf44
DEG_APCC_KENBOX_2
64:68
LKENP
APC,CDC20,FZR1
0.5525
More...