DegronMD

Uniprot ID: Q8IVW4

Source protein: Cyclin-dependent kinase-like 3

Source gene: CDKL3

Class: DEG_APCC_KENBOX_2

Location: 418:422

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6018

ASA_SCORE: 96.14

COIL: 0.9146

CONS_SCORE: 0.4207

DSS_SCORE: 0.5059

HELIX: 0.0348

FCONS_SCORE: 1.0433

RIG_SCORE: 0.6596

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L418F	TCGA-F4-6856	COAD	TCGA	LKENP	DEG_APCC_KENBOX_2	0.587
p.G417C	TCGA-D7-A6EY	STAD	TCGA	LKENP	DEG_APCC_KENBOX_2	0.3056
p.L415V	DO42961	UCEC	ICGC	LKENP	DEG_APCC_KENBOX_2	0.25
p.L415V	DO41349	UCEC	ICGC	LKENP	DEG_APCC_KENBOX_2	0.25
p.T413A	TCGA-56-8305	LUSC	TCGA	LKENP	DEG_APCC_KENBOX_2	0.1944
p.P411L	TCGA-90-A4ED	LUSC	TCGA	LKENP	DEG_APCC_KENBOX_2	0.1389
p.N410H	TCGA-BH-A18J	BRCA	TCGA	LKENP	DEG_APCC_KENBOX_2	0.1111

Showing 1 to 7 of 7 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IVW4	Cyclin-dependent kinase-like 3	DEG_APCC_KENBOX_2	418:422	LKENP	APC,CDC20,FZR1	0.6018	More...
Q8TAM6	Ermin	DEG_APCC_KENBOX_2	79:83	LKENP	APC,CDC20,FZR1	0.9084	More...
Q9UQ84	Exonuclease 1	DEG_APCC_KENBOX_2	390:394	LKENP	APC,CDC20,FZR1	0.9695	More...
Q96SB4	SRSF protein kinase 1	DEG_APCC_KENBOX_2	317:321	LKENP	APC,CDC20,FZR1	0.8488	More...
Q9BSI4	TERF1-interacting nuclear factor 2	DEG_APCC_KENBOX_2	340:344	LKENP	APC,CDC20,FZR1	0.8292	More...
Q9H6X5	Uncharacterized protein C19orf44	DEG_APCC_KENBOX_2	64:68	LKENP	APC,CDC20,FZR1	0.5525	More...

Showing 1 to 6 of 6 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons