DegronMD

Uniprot ID: Q96SB4

Source protein: SRSF protein kinase 1

Source gene: SRPK1

Class: DEG_APCC_KENBOX_2

Location: 317:321

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8488

ASA_SCORE: 110.3

COIL: 0.8948

CONS_SCORE: 0.3357

DSS_SCORE: 0.8189

HELIX: 0.0778

FCONS_SCORE: 0.9837

RIG_SCORE: 0.5747

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E308Q	TCGA-34-8454	LUSC	TCGA	LKENP	DEG_APCC_KENBOX_2	0.0833
p.E331K	TCGA-55-8302	LUAD	TCGA	LKENP	DEG_APCC_KENBOX_2	0.0556
p.E319D	TCGA-AA-3984	COAD	TCGA	LKENP	DEG_APCC_KENBOX_2	0.6758
p.K324E	TCGA-EE-A2GI	SKCM	TCGA	LKENP	DEG_APCC_KENBOX_2	0.3611
p.E319K	TCGA-QC-A7B5	SARC	TCGA	LKENP	DEG_APCC_KENBOX_2	0.7022
p.K318N	TCGA-QC-A7B5	SARC	TCGA	LKENP	DEG_APCC_KENBOX_2	0.6918
p.E310D	TCGA-VQ-A8P2	STAD	TCGA	LKENP	DEG_APCC_KENBOX_2	0.1389
p.Q324R	DO1658	BRCA	ICGC	LKENP	DEG_APCC_KENBOX_2	0.3611
p.C307Y	DO222574	BTCA	ICGC	LKENP	DEG_APCC_KENBOX_2	0.0556
p.C307Y	DO26898	LUSC	ICGC	LKENP	DEG_APCC_KENBOX_2	0.0556
p.D316H	DO44448	HNSC	ICGC	LKENP	DEG_APCC_KENBOX_2	0.3056
p.Q311K	DO228986	LICA	ICGC	LKENP	DEG_APCC_KENBOX_2	0.6111
p.E315K	DO45312	LUAD	ICGC	LKENP	DEG_APCC_KENBOX_2	0.2778
p.E314D	SIDM00845	Burkitt's Lymphoma	GDSC	LKENP	DEG_APCC_KENBOX_2	0.25
p.E314D	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	LKENP	DEG_APCC_KENBOX_2	0.25
p.K318T	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	LKENP	DEG_APCC_KENBOX_2	0.7306
p.D323Y	KNS-62	lung	COSMIC	LKENP	DEG_APCC_KENBOX_2	0.2778
p.Q324H	KNS-62	lung	COSMIC	LKENP	DEG_APCC_KENBOX_2	0.3611

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00588	HNSC\|head_and_neck	p.G476E (No)	GDSC	XMD11-85h	12.2083
SIDM01032	ESCA\|oesophagus	p.A10S (No)	GDSC	XMD11-85h	53.2231
SIDM00683	PRAD\|prostate	p.P245L (No)	GDSC	XMD11-85h	27.4782
SIDM00535	UNCLASSIFIED\|chondrosarcoma	p.C19S (No)	GDSC	XMD11-85h	104.443
SIDM00651	UNCLASSIFIED\|lung_NSCLC_large_cell	p.C356Y (No)	GDSC	XMD11-85h	53.1938
SIDM01090	COREAD\|large_intestine	p.I417V (No)	GDSC	XMD11-85h	32.6685
SIDM00711	SCLC\|lung_small_cell_carcinoma	p.R649L (No)	GDSC	XMD11-85h	328.3027
SIDM00946	ALL\|T_cell_leukemia	p.G297S (No)	GDSC	XMD11-85h	10.4455
SIDM00602	STAD\|stomach	p.G595fs*3 (No)	GDSC	XMD11-85h	131.3361
SIDM00999	BLCA\|bladder	p.V94I (No)	GDSC	XMD11-85h	23.1162
SIDM00898	BRCA\|breast	p.E57Q (No)	GDSC	XMD11-85h	52.3033
SIDM00540	HNSC\|head_and_neck	p.R649Q (No)	GDSC	XMD11-85h	35.0731
SIDM00839	COREAD\|large_intestine	p.R649Q (No)	GDSC	XMD11-85h	17.8041
SIDM00321	UNCLASSIFIED\|ovary	p.R126Q (No)	GDSC	XMD11-85h	22.8688
SIDM00047	LUAD\|lung_NSCLC_adenocarcinoma	p.R649L (No)	GDSC	XMD11-85h	24.1027
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.K318T (Yes)	GDSC	XMD11-85h	7.9834
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.E314D (Yes)	GDSC	XMD11-85h	7.9834
SIDM00987	THCA\|thyroid	p.R649Q (No)	GDSC	XMD11-85h	5.5729
SIDM00487	COREAD\|large_intestine	p.L608I (No)	GDSC	XMD11-85h	21.2454
SIDM00934	PAAD\|pancreas	p.S241F (No)	GDSC	XMD11-85h	181.2987
SIDM00193	COREAD\|large_intestine	p.F508L (No)	GDSC	XMD11-85h	111.2169
SIDM00118	COREAD\|large_intestine	p.N355K (No)	GDSC	XMD11-85h	16.135

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IVW4	Cyclin-dependent kinase-like 3	DEG_APCC_KENBOX_2	418:422	LKENP	APC,CDC20,FZR1	0.6018	More...
Q8TAM6	Ermin	DEG_APCC_KENBOX_2	79:83	LKENP	APC,CDC20,FZR1	0.9084	More...
Q96SB4	SRSF protein kinase 1	DEG_APCC_KENBOX_2	317:321	LKENP	APC,CDC20,FZR1	0.8488	More...
Q9BSI4	TERF1-interacting nuclear factor 2	DEG_APCC_KENBOX_2	340:344	LKENP	APC,CDC20,FZR1	0.8292	More...
Q9UQ84	Exonuclease 1	DEG_APCC_KENBOX_2	390:394	LKENP	APC,CDC20,FZR1	0.9695	More...
Q9H6X5	Uncharacterized protein C19orf44	DEG_APCC_KENBOX_2	64:68	LKENP	APC,CDC20,FZR1	0.5525	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons