DegronMD

Uniprot ID: Q8IZ07

Source protein: Ankyrin repeat domain-containing protein 13A

Source gene: ANKRD13A

Class: DEG_APCC_KENBOX_2

Location: 68:72

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.723

ASA_SCORE: 78

COIL: 0.7752

CONS_SCORE: 0.5015

DSS_SCORE: 0.2961

HELIX: 0.0506

FCONS_SCORE: 0.8056

RIG_SCORE: 0.75

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R72C	TCGA-A6-2686	COAD	TCGA	TKENR	DEG_APCC_KENBOX_2	0.719
p.R72C	TCGA-AG-A002	READ	TCGA	TKENR	DEG_APCC_KENBOX_2	0.719
p.R72C	TCGA-AZ-4315	COAD	TCGA	TKENR	DEG_APCC_KENBOX_2	0.719
p.R72C	DO7828	COAD	ICGC	TKENR	DEG_APCC_KENBOX_2	0.719
p.R72C	DO8842	COAD	ICGC	TKENR	DEG_APCC_KENBOX_2	0.719
p.V67M	TCGA-EE-A184	SKCM	TCGA	TKENR	DEG_APCC_KENBOX_2	0.3056
p.V67M	DO47442	SKCM	ICGC	TKENR	DEG_APCC_KENBOX_2	0.3056
p.A65T	TCGA-B5-A0K2	UCEC	TCGA	TKENR	DEG_APCC_KENBOX_2	0.25
p.A65T	DO43835	UCEC	ICGC	TKENR	DEG_APCC_KENBOX_2	0.25
p.H63R	SIDM01781	Gastric Carcinoma	GDSC	TKENR	DEG_APCC_KENBOX_2	0.1944
p.H63R	ACH-000325	Gastric Cancer	CCLE	TKENR	DEG_APCC_KENBOX_2	0.1944
p.A81V	TCGA-IB-7651	PAAD	TCGA	TKENR	DEG_APCC_KENBOX_2	0.0833
p.A81V	DO46657	PAAD	ICGC	TKENR	DEG_APCC_KENBOX_2	0.0833
p.V82L	DO228986	LICA	ICGC	TKENR	DEG_APCC_KENBOX_2	0.0556

Showing 1 to 14 of 14 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IZ07	Ankyrin repeat domain-containing protein 13A	DEG_APCC_KENBOX_2	68:72	TKENR	APC,CDC20,FZR1	0.723	More...
Q9BSD7	Cancer-related nucleoside-triphosphatase	DEG_APCC_KENBOX_2	170:174	TKENR	APC,CDC20,FZR1	0.7693	More...
P05060	Secretogranin-1	DEG_APCC_KENBOX_2	492:496	TKENR	APC,CDC20,FZR1	0.9841	More...
Q12923	Tyrosine-protein phosphatase non-receptor type 13	DEG_APCC_KENBOX_2	2234:2238	TKENR	APC,CDC20,FZR1	0.6328	More...

Showing 1 to 4 of 4 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons