DegronMD

Uniprot ID: Q12923

Source protein: Tyrosine-protein phosphatase non-receptor type 13

Source gene: PTPN13

Class: DEG_APCC_DBOX_1

Location: 1221:1229

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9704

ASA_SCORE: 81.4778

COIL: 0.7063

CONS_SCORE: 0.3278

DSS_SCORE: 0.5428

HELIX: 0.0838

FCONS_SCORE: 0.8647

RIG_SCORE: 0.6812

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1222C	TCGA-AP-A0LP	UCEC	TCGA	SRGTLRHIS	DEG_APCC_DBOX_1	0.8301
p.R1222C	DO43146	UCEC	ICGC	SRGTLRHIS	DEG_APCC_DBOX_1	0.8301
p.L1225M	TCGA-BJ-A191	THCA	TCGA	SRGTLRHIS	DEG_APCC_DBOX_1	0.711
p.L1225M	DO40167	THCA	ICGC	SRGTLRHIS	DEG_APCC_DBOX_1	0.711
p.E1230D	TCGA-EO-A22X	UCEC	TCGA	SRGTLRHIS	DEG_APCC_DBOX_1	0.3056
p.E1230D	DO43907	UCEC	ICGC	SRGTLRHIS	DEG_APCC_DBOX_1	0.3056
p.D1212H	TCGA-MA-AA42	CESC	TCGA	SRGTLRHIS	DEG_APCC_DBOX_1	0.0833
p.D1212H	DO219724	CESC	ICGC	SRGTLRHIS	DEG_APCC_DBOX_1	0.0833
p.G1238D	DO225070	BRCA	ICGC	SRGTLRHIS	DEG_APCC_DBOX_1	0.0833
p.G1237E	SIDM00087	Plasma Cell Myeloma	GDSC	SRGTLRHIS	DEG_APCC_DBOX_1	0.1111
p.G1237E	ACH-000817	Myeloma	CCLE	SRGTLRHIS	DEG_APCC_DBOX_1	0.1111
p.G1237E	RPMI-8226	haematopoietic_and_lymphoid_tissue	COSMIC	SRGTLRHIS	DEG_APCC_DBOX_1	0.1111
p.R1222G	SIDM00090	Ovarian Carcinoma	GDSC	SRGTLRHIS	DEG_APCC_DBOX_1	0.7568
p.R1222G	ACH-000696	Ovarian Cancer	CCLE	SRGTLRHIS	DEG_APCC_DBOX_1	0.7568
p.R1222G	OVCAR-8	ovary	COSMIC	SRGTLRHIS	DEG_APCC_DBOX_1	0.7568
p.L1228P	KYSE-270	oesophagus	COSMIC	SRGTLRHIS	DEG_APCC_DBOX_1	0.7582
p.A1235T	COLO-668	lung	COSMIC	SRGTLRHIS	DEG_APCC_DBOX_1	0.1667
p.G1218E	RPMI-8226	haematopoietic_and_lymphoid_tissue	COSMIC	SRGTLRHIS	DEG_APCC_DBOX_1	0.25
p.R1226C	NCI-SNU-1	stomach	COSMIC	SRGTLRHIS	DEG_APCC_DBOX_1	0.719
p.R1226C	MOLT-16	haematopoietic_and_lymphoid_tissue	COSMIC	SRGTLRHIS	DEG_APCC_DBOX_1	0.719

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12923	Tyrosine-protein phosphatase non-receptor type 13	DEG_APCC_DBOX_1	1221:1229	SRGTLRHIS	APC,CDC20,FZR1	0.9704	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons