DegronMD

Uniprot ID: Q12923

Source protein: Tyrosine-protein phosphatase non-receptor type 13

Source gene: PTPN13

Class: DEG_APCC_KENBOX_2

Location: 1071:1075

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9955

ASA_SCORE: 99.38

COIL: 0.7272

CONS_SCORE: 0.3422

DSS_SCORE: 0.4031

HELIX: 0.2196

FCONS_SCORE: 1.0215

RIG_SCORE: 0.7276

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L1071V	TCGA-A5-A1OF	UCEC	TCGA	LKEND	DEG_APCC_KENBOX_2	0.5654
p.L1071V	DO42568	UCEC	ICGC	LKEND	DEG_APCC_KENBOX_2	0.5654
p.V1076G	TCGA-A5-A1OF	UCEC	TCGA	LKEND	DEG_APCC_KENBOX_2	0.3056
p.V1076G	DO42568	UCEC	ICGC	LKEND	DEG_APCC_KENBOX_2	0.3056
p.K1072Q	TCGA-AG-A002	READ	TCGA	LKEND	DEG_APCC_KENBOX_2	0.6944
p.S1085Y	TCGA-EO-A22R	UCEC	TCGA	LKEND	DEG_APCC_KENBOX_2	0.5
p.S1085Y	DO42713	UCEC	ICGC	LKEND	DEG_APCC_KENBOX_2	0.5
p.S1067F	TCGA-OD-A75X	SKCM	TCGA	LKEND	DEG_APCC_KENBOX_2	0.2222
p.S1067F	DO48601	SKCM	ICGC	LKEND	DEG_APCC_KENBOX_2	0.2222
p.S1082N	DO233107	GACA	ICGC	LKEND	DEG_APCC_KENBOX_2	0.5833
p.N1074H	DO233951	GACA	ICGC	LKEND	DEG_APCC_KENBOX_2	0.7423
p.V1069A	DO45265	LIRI	ICGC	LKEND	DEG_APCC_KENBOX_2	0.2778
p.V1069I	DO229177	LMS	ICGC	LKEND	DEG_APCC_KENBOX_2	0.2778
p.W1081C	ACH-001407	Bladder Cancer	CCLE	LKEND	DEG_APCC_KENBOX_2	0.1667
p.A1063T	COLO-668	lung	COSMIC	LKEND	DEG_APCC_KENBOX_2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15344	E3 ubiquitin-protein ligase Midline-1	DEG_APCC_KENBOX_2	320:324	LKEND	APC,CDC20,FZR1	0.7656	More...
P29374	AT-rich interactive domain-containing protein 4A	DEG_APCC_KENBOX_2	744:748	LKEND	APC,CDC20,FZR1	0.5299	More...
P46013	Proliferation marker protein Ki-67	DEG_APCC_KENBOX_2	938:942	LKEND	APC,CDC20,FZR1	0.9316	More...
Q12923	Tyrosine-protein phosphatase non-receptor type 13	DEG_APCC_KENBOX_2	1071:1075	LKEND	APC,CDC20,FZR1	0.9955	More...
Q14739	Delta	DEG_APCC_KENBOX_2	49:53	LKEND	APC,CDC20,FZR1	0.9324	More...
Q8NI35	InaD-like protein	DEG_APCC_KENBOX_2	179:183	LKEND	APC,CDC20,FZR1	0.9898	More...
Q92743	Serine protease HTRA1	DEG_APCC_KENBOX_2	428:432	LKEND	APC,CDC20,FZR1	0.9566	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons