DegronMD

Uniprot ID: Q14739

Source protein: Delta

Source gene: LBR

Class: DEG_APCC_KENBOX_2

Location: 49:53

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9324

ASA_SCORE: 85.62

COIL: 0.5558

CONS_SCORE: 0.256

DSS_SCORE: 0.482

HELIX: 0.2704

FCONS_SCORE: 0.9756

RIG_SCORE: 0.8024

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E48A	TCGA-BS-A0TC	UCEC	TCGA	LKEND	DEG_APCC_KENBOX_2	0.3056
p.E48A	DO42400	UCEC	ICGC	LKEND	DEG_APCC_KENBOX_2	0.3056
p.N52K	TCGA-FR-A726	SKCM	TCGA	LKEND	DEG_APCC_KENBOX_2	0.6918
p.N52K	DO48665	SKCM	ICGC	LKEND	DEG_APCC_KENBOX_2	0.6918
p.S59F	TCGA-QB-A6FS	SKCM	TCGA	LKEND	DEG_APCC_KENBOX_2	0.6111
p.S59F	DO48654	SKCM	ICGC	LKEND	DEG_APCC_KENBOX_2	0.6111
p.N52S	TCGA-R6-A6XQ	ESCA	TCGA	LKEND	DEG_APCC_KENBOX_2	0.7069
p.E51D	DO222884	COCA	ICGC	LKEND	DEG_APCC_KENBOX_2	0.6758
p.K40N	DO46518	OV	ICGC	LKEND	DEG_APCC_KENBOX_2	0.1944
p.E48K	SIDM00915	Small Cell Lung Carcinoma	GDSC	LKEND	DEG_APCC_KENBOX_2	0.3056
p.E48K	NCI-H378	lung	COSMIC	LKEND	DEG_APCC_KENBOX_2	0.3056
p.D43Y	ACH-000075	Brain Cancer	CCLE	LKEND	DEG_APCC_KENBOX_2	0.1667
p.E48G	ACH-001541	Myeloma	CCLE	LKEND	DEG_APCC_KENBOX_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15344	E3 ubiquitin-protein ligase Midline-1	DEG_APCC_KENBOX_2	320:324	LKEND	APC,CDC20,FZR1	0.7656	More...
P29374	AT-rich interactive domain-containing protein 4A	DEG_APCC_KENBOX_2	744:748	LKEND	APC,CDC20,FZR1	0.5299	More...
P46013	Proliferation marker protein Ki-67	DEG_APCC_KENBOX_2	938:942	LKEND	APC,CDC20,FZR1	0.9316	More...
Q12923	Tyrosine-protein phosphatase non-receptor type 13	DEG_APCC_KENBOX_2	1071:1075	LKEND	APC,CDC20,FZR1	0.9955	More...
Q14739	Delta	DEG_APCC_KENBOX_2	49:53	LKEND	APC,CDC20,FZR1	0.9324	More...
Q8NI35	InaD-like protein	DEG_APCC_KENBOX_2	179:183	LKEND	APC,CDC20,FZR1	0.9898	More...
Q92743	Serine protease HTRA1	DEG_APCC_KENBOX_2	428:432	LKEND	APC,CDC20,FZR1	0.9566	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons