DegronMD - Q92743(HTRA1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S441F	TCGA-AA-3977	COAD	TCGA	LKEND	DEG_APCC_KENBOX_2	428:432	Mutation rewiring degron network	0.0833
p.S441F	DO8730	COAD	ICGC	LKEND	DEG_APCC_KENBOX_2	428:432	Mutation rewiring degron network	0.0833
p.V433A	TCGA-AJ-A3EL	UCEC	TCGA	LKEND	DEG_APCC_KENBOX_2	428:432	Mutation rewiring degron network	0.3056
p.V433A	DO41542	UCEC	ICGC	LKEND	DEG_APCC_KENBOX_2	428:432	Mutation rewiring degron network	0.3056
p.D432N	TCGA-AP-A056	UCEC	TCGA	LKEND	DEG_APCC_KENBOX_2	428:432	Mutation altering degron motif	0.5821
p.D432N	TCGA-EB-A431	SKCM	TCGA	LKEND	DEG_APCC_KENBOX_2	428:432	Mutation altering degron motif	0.5821
p.D432N	DO37671	SKCM	ICGC	LKEND	DEG_APCC_KENBOX_2	428:432	Mutation altering degron motif	0.5821
p.D432N	DO43971	UCEC	ICGC	LKEND	DEG_APCC_KENBOX_2	428:432	Mutation altering degron motif	0.5821
p.I434T	TCGA-BR-6458	STAD	TCGA	LKEND	DEG_APCC_KENBOX_2	428:432	Mutation rewiring degron network	0.2778
p.I434T	DO38296	STAD	ICGC	LKEND	DEG_APCC_KENBOX_2	428:432	Mutation rewiring degron network	0.2778
p.T421I	TCGA-BR-8680	STAD	TCGA	LKEND	DEG_APCC_KENBOX_2	428:432	Mutation rewiring degron network	0.1389
p.T421I	DO47769	STAD	ICGC	LKEND	DEG_APCC_KENBOX_2	428:432	Mutation rewiring degron network	0.1389
p.D420Y	TCGA-D3-A3C8	SKCM	TCGA	LKEND	DEG_APCC_KENBOX_2	428:432	Mutation rewiring degron network	0.1111
p.D420Y	DO47636	SKCM	ICGC	LKEND	DEG_APCC_KENBOX_2	428:432	Mutation rewiring degron network	0.1111
p.V433I	TCGA-D5-6928	COAD	TCGA	LKEND	DEG_APCC_KENBOX_2	428:432	Mutation rewiring degron network	0.3056
p.V433I	TCGA-EE-A2A2	SKCM	TCGA	LKEND	DEG_APCC_KENBOX_2	428:432	Mutation rewiring degron network	0.3056
p.V433I	TCGA-GM-A2DB	BRCA	TCGA	LKEND	DEG_APCC_KENBOX_2	428:432	Mutation rewiring degron network	0.3056
p.V433I	DO5179	BRCA	ICGC	LKEND	DEG_APCC_KENBOX_2	428:432	Mutation rewiring degron network	0.3056
p.V433I	DO7776	COAD	ICGC	LKEND	DEG_APCC_KENBOX_2	428:432	Mutation rewiring degron network	0.3056
p.V433I	DO37583	SKCM	ICGC	LKEND	DEG_APCC_KENBOX_2	428:432	Mutation rewiring degron network	0.3056
p.E430K	TCGA-EE-A3JD	SKCM	TCGA	LKEND	DEG_APCC_KENBOX_2	428:432	Mutation altering degron motif	0.7022
p.E430K	DO229453	SKCA	ICGC	LKEND	DEG_APCC_KENBOX_2	428:432	Mutation altering degron motif	0.7022
p.E430K	DO50299	SKCM	ICGC	LKEND	DEG_APCC_KENBOX_2	428:432	Mutation altering degron motif	0.7022
p.T421N	DO234270	ESAD	ICGC	LKEND	DEG_APCC_KENBOX_2	428:432	Mutation rewiring degron network	0.1389
p.V442M	DO233652	GACA	ICGC	LKEND	DEG_APCC_KENBOX_2	428:432	Mutation rewiring degron network	0.0556
p.S436N	SIDM00537	Colorectal Carcinoma	GDSC	LKEND	DEG_APCC_KENBOX_2	428:432	Mutation rewiring degron network	0.2222
p.S436N	ACH-000982	Colon/Colorectal Cancer	CCLE	LKEND	DEG_APCC_KENBOX_2	428:432	Mutation rewiring degron network	0.2222
p.S436N	ACH-001345	Colon/Colorectal Cancer	CCLE	LKEND	DEG_APCC_KENBOX_2	428:432	Mutation rewiring degron network	0.2222
p.S436N	GP5d	large intestine	COSMIC	LKEND	DEG_APCC_KENBOX_2	428:432	Mutation rewiring degron network	0.2222

Kaplan plot for HTRA1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

HTRA1

UniProt ID: Q92743

Entrez ID: 5654

Protein name: Serine protease HTRA1 (EC 3.4.21.-) (High-temperature requirement A serine peptidase 1) (L56) (Serine protease 11)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for HTRA1 in