DegronMD

Uniprot ID: Q92743

Source protein: Serine protease HTRA1

Source gene: HTRA1

Class: DEG_APCC_KENBOX_2

Location: 428:432

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9566

ASA_SCORE: 69

COIL: 0.978

CONS_SCORE: 0.6399

DSS_SCORE: 0.3262

HELIX: 0.0056

FCONS_SCORE: 1.246

RIG_SCORE: 0.8125

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S441F	TCGA-AA-3977	COAD	TCGA	LKEND	DEG_APCC_KENBOX_2	0.0833
p.S441F	DO8730	COAD	ICGC	LKEND	DEG_APCC_KENBOX_2	0.0833
p.V433A	TCGA-AJ-A3EL	UCEC	TCGA	LKEND	DEG_APCC_KENBOX_2	0.3056
p.V433A	DO41542	UCEC	ICGC	LKEND	DEG_APCC_KENBOX_2	0.3056
p.D432N	TCGA-AP-A056	UCEC	TCGA	LKEND	DEG_APCC_KENBOX_2	0.5821
p.D432N	TCGA-EB-A431	SKCM	TCGA	LKEND	DEG_APCC_KENBOX_2	0.5821
p.D432N	DO37671	SKCM	ICGC	LKEND	DEG_APCC_KENBOX_2	0.5821
p.D432N	DO43971	UCEC	ICGC	LKEND	DEG_APCC_KENBOX_2	0.5821
p.I434T	TCGA-BR-6458	STAD	TCGA	LKEND	DEG_APCC_KENBOX_2	0.2778
p.I434T	DO38296	STAD	ICGC	LKEND	DEG_APCC_KENBOX_2	0.2778
p.T421I	TCGA-BR-8680	STAD	TCGA	LKEND	DEG_APCC_KENBOX_2	0.1389
p.T421I	DO47769	STAD	ICGC	LKEND	DEG_APCC_KENBOX_2	0.1389
p.D420Y	TCGA-D3-A3C8	SKCM	TCGA	LKEND	DEG_APCC_KENBOX_2	0.1111
p.D420Y	DO47636	SKCM	ICGC	LKEND	DEG_APCC_KENBOX_2	0.1111
p.V433I	TCGA-D5-6928	COAD	TCGA	LKEND	DEG_APCC_KENBOX_2	0.3056
p.V433I	TCGA-EE-A2A2	SKCM	TCGA	LKEND	DEG_APCC_KENBOX_2	0.3056
p.V433I	TCGA-GM-A2DB	BRCA	TCGA	LKEND	DEG_APCC_KENBOX_2	0.3056
p.V433I	DO5179	BRCA	ICGC	LKEND	DEG_APCC_KENBOX_2	0.3056
p.V433I	DO7776	COAD	ICGC	LKEND	DEG_APCC_KENBOX_2	0.3056
p.V433I	DO37583	SKCM	ICGC	LKEND	DEG_APCC_KENBOX_2	0.3056
p.E430K	TCGA-EE-A3JD	SKCM	TCGA	LKEND	DEG_APCC_KENBOX_2	0.7022
p.E430K	DO229453	SKCA	ICGC	LKEND	DEG_APCC_KENBOX_2	0.7022
p.E430K	DO50299	SKCM	ICGC	LKEND	DEG_APCC_KENBOX_2	0.7022
p.T421N	DO234270	ESAD	ICGC	LKEND	DEG_APCC_KENBOX_2	0.1389
p.V442M	DO233652	GACA	ICGC	LKEND	DEG_APCC_KENBOX_2	0.0556
p.S436N	SIDM00537	Colorectal Carcinoma	GDSC	LKEND	DEG_APCC_KENBOX_2	0.2222
p.S436N	ACH-000982	Colon/Colorectal Cancer	CCLE	LKEND	DEG_APCC_KENBOX_2	0.2222
p.S436N	ACH-001345	Colon/Colorectal Cancer	CCLE	LKEND	DEG_APCC_KENBOX_2	0.2222
p.S436N	GP5d	large_intestine	COSMIC	LKEND	DEG_APCC_KENBOX_2	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15344	E3 ubiquitin-protein ligase Midline-1	DEG_APCC_KENBOX_2	320:324	LKEND	APC,CDC20,FZR1	0.7656	More...
P29374	AT-rich interactive domain-containing protein 4A	DEG_APCC_KENBOX_2	744:748	LKEND	APC,CDC20,FZR1	0.5299	More...
P46013	Proliferation marker protein Ki-67	DEG_APCC_KENBOX_2	938:942	LKEND	APC,CDC20,FZR1	0.9316	More...
Q12923	Tyrosine-protein phosphatase non-receptor type 13	DEG_APCC_KENBOX_2	1071:1075	LKEND	APC,CDC20,FZR1	0.9955	More...
Q14739	Delta	DEG_APCC_KENBOX_2	49:53	LKEND	APC,CDC20,FZR1	0.9324	More...
Q8NI35	InaD-like protein	DEG_APCC_KENBOX_2	179:183	LKEND	APC,CDC20,FZR1	0.9898	More...
Q92743	Serine protease HTRA1	DEG_APCC_KENBOX_2	428:432	LKEND	APC,CDC20,FZR1	0.9566	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LKEND

Degron related mutations and impact score

Drug responses associated with HTRA1 mutations

All proteins holding degron of LKEND