DegronMD

Uniprot ID: Q12923

Source protein: Tyrosine-protein phosphatase non-receptor type 13

Source gene: PTPN13

Class: DEG_SCF_FBW7_1

Location: 1600:1606

E3 ligase: FBXW7

DEGRON score: 0.9939

ASA_SCORE: 76.4571

COIL: 0.853

CONS_SCORE: 0.491

DSS_SCORE: 0.4294

HELIX: 0.1157

FCONS_SCORE: 1.1546

RIG_SCORE: 0.7689

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I1601M	TCGA-AN-A046	BRCA	TCGA	LLTPLQS	DEG_SCF_FBW7_1	0.7618
p.I1601M	DO1285	BRCA	ICGC	LLTPLQS	DEG_SCF_FBW7_1	0.7618
p.A1613T	TCGA-DA-A95X	SKCM	TCGA	LLTPLQS	DEG_SCF_FBW7_1	0.1389
p.A1613T	DO219480	SKCM	ICGC	LLTPLQS	DEG_SCF_FBW7_1	0.1389
p.S1611Y	DO222884	COCA	ICGC	LLTPLQS	DEG_SCF_FBW7_1	0.1944
p.G1596C	DO50880	LICA	ICGC	LLTPLQS	DEG_SCF_FBW7_1	0.2222
p.N1616D	DO222843	MELA	ICGC	LLTPLQS	DEG_SCF_FBW7_1	0.1667
p.L1597H	DO32337	OV	ICGC	LLTPLQS	DEG_SCF_FBW7_1	0.25
p.P1595L	DO218863	SKCA	ICGC	LLTPLQS	DEG_SCF_FBW7_1	0.1944
p.L1600I	DO37707	SKCM	ICGC	LLTPLQS	DEG_SCF_FBW7_1	0.6063
p.G1615D	DO42280	UCEC	ICGC	LLTPLQS	DEG_SCF_FBW7_1	0.0833
p.P1593S	SIDM00250	Esophageal Squamous Cell Carcinoma	GDSC	LLTPLQS	DEG_SCF_FBW7_1	0.1389
p.P1593S	ACH-000917	Esophageal Cancer	CCLE	LLTPLQS	DEG_SCF_FBW7_1	0.1389
p.P1593S	TE-4	oesophagus	COSMIC	LLTPLQS	DEG_SCF_FBW7_1	0.1389
p.A1613P	SIDM00884	Breast Carcinoma	GDSC	LLTPLQS	DEG_SCF_FBW7_1	0.1389
p.A1613P	HCC1395	breast	COSMIC	LLTPLQS	DEG_SCF_FBW7_1	0.1389
p.T1603A	SIDM01618	B-Lymphoblastic Leukemia	GDSC	LLTPLQS	DEG_SCF_FBW7_1	0.7139
p.T1603A	ACH-000942	Leukemia	CCLE	LLTPLQS	DEG_SCF_FBW7_1	0.7139
p.A1608P	HCC1395	breast	COSMIC	LLTPLQS	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12923	Tyrosine-protein phosphatase non-receptor type 13	DEG_SCF_FBW7_1	1600:1606	LLTPLQS	FBXW7	0.9939	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons