DegronMD

Uniprot ID: P46013

Source protein: Proliferation marker protein Ki-67

Source gene: MKI67

Class: DEG_SCF_FBW7_1

Location: 1230:1237

E3 ligase: FBXW7

DEGRON score: 0.9924

ASA_SCORE: 88.4875

COIL: 0.8423

CONS_SCORE: 0.6266

DSS_SCORE: 0.4929

HELIX: 0.0731

FCONS_SCORE: 1.3086

RIG_SCORE: 0.7102

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1243T	TCGA-AA-A01R	COAD	TCGA	LFQTPGHT	DEG_SCF_FBW7_1	0.1667
p.L1221I	TCGA-AJ-A3EK	UCEC	TCGA	LFQTPGHT	DEG_SCF_FBW7_1	0.0833
p.A1225T	TCGA-AP-A1DK	UCEC	TCGA	LFQTPGHT	DEG_SCF_FBW7_1	0.1944
p.Q1232H	TCGA-GU-AATO	BLCA	TCGA	LFQTPGHT	DEG_SCF_FBW7_1	0.647
p.E1226D	DO1083	BRCA	ICGC	LFQTPGHT	DEG_SCF_FBW7_1	0.2222
p.E1243D	DO1285	BRCA	ICGC	LFQTPGHT	DEG_SCF_FBW7_1	0.1667
p.A1224D	DO228948	LICA	ICGC	LFQTPGHT	DEG_SCF_FBW7_1	0.1667
p.A1224D	DO229009	LICA	ICGC	LFQTPGHT	DEG_SCF_FBW7_1	0.1667
p.D1227E	DO228950	LICA	ICGC	LFQTPGHT	DEG_SCF_FBW7_1	0.25
p.A1229T	DO219157	LUSC	ICGC	LFQTPGHT	DEG_SCF_FBW7_1	0.3056
p.M1245I	DO27032	LUSC	ICGC	LFQTPGHT	DEG_SCF_FBW7_1	0.5556
p.M1245I	KM-H2	haematopoietic_and_lymphoid_tissue	COSMIC	LFQTPGHT	DEG_SCF_FBW7_1	0.5556
p.R1238Q	DO46657	PAAD	ICGC	LFQTPGHT	DEG_SCF_FBW7_1	0.3056
p.R1238Q	DO43186	UCEC	ICGC	LFQTPGHT	DEG_SCF_FBW7_1	0.3056
p.H1240R	DO50293	SKCM	ICGC	LFQTPGHT	DEG_SCF_FBW7_1	0.25
p.A1222V	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	LFQTPGHT	DEG_SCF_FBW7_1	0.1111
p.L1234F	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	LFQTPGHT	DEG_SCF_FBW7_1	0.6981
p.Q1223R	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	LFQTPGHT	DEG_SCF_FBW7_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P46013	Proliferation marker protein Ki-67	DEG_SCF_FBW7_1	1230:1237	LFQTPGHT	FBXW7	0.9924	More...
P46013	Proliferation marker protein Ki-67	DEG_SCF_FBW7_1	1352:1359	LFQTPGHT	FBXW7	0.9911	More...
P46013	Proliferation marker protein Ki-67	DEG_SCF_FBW7_1	1960:1967	LFQTPGHT	FBXW7	0.9775	More...
P46013	Proliferation marker protein Ki-67	DEG_SCF_FBW7_1	2443:2450	LFQTPGHT	FBXW7	0.9018	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons