DegronMD

Uniprot ID: P46013

Source protein: Proliferation marker protein Ki-67

Source gene: MKI67

Class: DEG_SCF_FBW7_1

Location: 2443:2450

E3 ligase: FBXW7

DEGRON score: 0.9018

ASA_SCORE: 95.875

COIL: 0.8964

CONS_SCORE: 0.2902

DSS_SCORE: 0.5822

HELIX: 0.0243

FCONS_SCORE: 1.0433

RIG_SCORE: 0.6767

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E2435D	TCGA-A5-A0G2	UCEC	TCGA	LFQTPGHT	DEG_SCF_FBW7_1	0.1111
p.T2455N	TCGA-AA-A010	COAD	TCGA	LFQTPGHT	DEG_SCF_FBW7_1	0.6389
p.D2436G	TCGA-HT-7882	LGG	TCGA	LFQTPGHT	DEG_SCF_FBW7_1	0.1389
p.S2433N	DO228483	BRCA	ICGC	LFQTPGHT	DEG_SCF_FBW7_1	0.0556
p.S2433N	DO229010	COCA	ICGC	LFQTPGHT	DEG_SCF_FBW7_1	0.0556
p.S2433N	DO229013	COCA	ICGC	LFQTPGHT	DEG_SCF_FBW7_1	0.0556
p.S2433N	DO229016	COCA	ICGC	LFQTPGHT	DEG_SCF_FBW7_1	0.0556
p.S2433N	DO229480	LAML	ICGC	LFQTPGHT	DEG_SCF_FBW7_1	0.0556
p.S2433N	DO231075	LUSC	ICGC	LFQTPGHT	DEG_SCF_FBW7_1	0.0556
p.A2441D	DO12184	GBM	ICGC	LFQTPGHT	DEG_SCF_FBW7_1	0.7222
p.E2438G	DO14250	HNSC	ICGC	LFQTPGHT	DEG_SCF_FBW7_1	0.1944
p.E2438K	DO222395	MELA	ICGC	LFQTPGHT	DEG_SCF_FBW7_1	0.1944
p.D2439Y	DO51474	PACA	ICGC	LFQTPGHT	DEG_SCF_FBW7_1	0.2222
p.T2460I	DO50281	SKCM	ICGC	LFQTPGHT	DEG_SCF_FBW7_1	0.5
p.Q2435H	DO41133	UCEC	ICGC	LFQTPGHT	DEG_SCF_FBW7_1	0.1111
p.T2456A	DO42745	UCEC	ICGC	LFQTPGHT	DEG_SCF_FBW7_1	0.1667
p.T2460A	DO42633	UCEC	ICGC	LFQTPGHT	DEG_SCF_FBW7_1	0.5
p.S2453L	SIDM00995	Other Solid Cancers	GDSC	LFQTPGHT	DEG_SCF_FBW7_1	0.6944
p.S2453L	ACH-001328	Skin Cancer	CCLE	LFQTPGHT	DEG_SCF_FBW7_1	0.6944
p.S2453L	A431	skin	COSMIC	LFQTPGHT	DEG_SCF_FBW7_1	0.6944
p.K2441E	SIDM00878	Breast Carcinoma	GDSC	LFQTPGHT	DEG_SCF_FBW7_1	0.7222
p.K2441E	ACH-000930	Breast Cancer	CCLE	LFQTPGHT	DEG_SCF_FBW7_1	0.7222
p.K2441E	HCC1569	breast	COSMIC	LFQTPGHT	DEG_SCF_FBW7_1	0.7222
p.G2448D	SIDM00554	Ovarian Carcinoma	GDSC	LFQTPGHT	DEG_SCF_FBW7_1	0.6087
p.G2448D	ACH-000524	Ovarian Cancer	CCLE	LFQTPGHT	DEG_SCF_FBW7_1	0.6087
p.G2448D	KURAMOCHI	ovary	COSMIC	LFQTPGHT	DEG_SCF_FBW7_1	0.6087

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P46013	Proliferation marker protein Ki-67	DEG_SCF_FBW7_1	1230:1237	LFQTPGHT	FBXW7	0.9924	More...
P46013	Proliferation marker protein Ki-67	DEG_SCF_FBW7_1	1352:1359	LFQTPGHT	FBXW7	0.9911	More...
P46013	Proliferation marker protein Ki-67	DEG_SCF_FBW7_1	1960:1967	LFQTPGHT	FBXW7	0.9775	More...
P46013	Proliferation marker protein Ki-67	DEG_SCF_FBW7_1	2443:2450	LFQTPGHT	FBXW7	0.9018	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LFQTPGHT

Degron related mutations and impact score

Drug responses associated with MKI67 mutations

All proteins holding degron of LFQTPGHT