DegronMD

Uniprot ID: P46013

Source protein: Proliferation marker protein Ki-67

Source gene: MKI67

Class: DEG_SCF_FBW7_1

Location: 1352:1359

E3 ligase: FBXW7

DEGRON score: 0.9911

ASA_SCORE: 88.9375

COIL: 0.8496

CONS_SCORE: 0.5415

DSS_SCORE: 0.6201

HELIX: 0.0604

FCONS_SCORE: 1.5128

RIG_SCORE: 0.6866

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1351K	TCGA-73-A9RS	LUAD	TCGA	LFQTPGHT	DEG_SCF_FBW7_1	0.3056
p.P1356L	TCGA-AB-2828	LAML	TCGA	LFQTPGHT	DEG_SCF_FBW7_1	0.7582
p.E1361D	TCGA-AP-A0LM	UCEC	TCGA	LFQTPGHT	DEG_SCF_FBW7_1	0.2778
p.E1345K	DO496	BLCA	ICGC	LFQTPGHT	DEG_SCF_FBW7_1	0.1389
p.E1355K	DO496	BLCA	ICGC	LFQTPGHT	DEG_SCF_FBW7_1	0.7022
p.E1355K	DO51167	GBM	ICGC	LFQTPGHT	DEG_SCF_FBW7_1	0.7022
p.M1367I	DO220827	BRCA	ICGC	LFQTPGHT	DEG_SCF_FBW7_1	0.5556
p.G1352A	DO23220	LINC	ICGC	LFQTPGHT	DEG_SCF_FBW7_1	0.754
p.G1366A	SIDM01117	Small Cell Lung Carcinoma	GDSC	LFQTPGHT	DEG_SCF_FBW7_1	0.1389
p.G1366A	ACH-002176	Lung Cancer	CCLE	LFQTPGHT	DEG_SCF_FBW7_1	0.1389
p.G1366A	NCI-H748	lung	COSMIC	LFQTPGHT	DEG_SCF_FBW7_1	0.1389
p.S1344C	OVKATE	ovary	COSMIC	LFQTPGHT	DEG_SCF_FBW7_1	0.1111
p.P1347S	HCC-366	lung	COSMIC	LFQTPGHT	DEG_SCF_FBW7_1	0.6389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P46013	Proliferation marker protein Ki-67	DEG_SCF_FBW7_1	1230:1237	LFQTPGHT	FBXW7	0.9924	More...
P46013	Proliferation marker protein Ki-67	DEG_SCF_FBW7_1	1352:1359	LFQTPGHT	FBXW7	0.9911	More...
P46013	Proliferation marker protein Ki-67	DEG_SCF_FBW7_1	1960:1967	LFQTPGHT	FBXW7	0.9775	More...
P46013	Proliferation marker protein Ki-67	DEG_SCF_FBW7_1	2443:2450	LFQTPGHT	FBXW7	0.9018	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons