DegronMD

Uniprot ID: P46013

Source protein: Proliferation marker protein Ki-67

Source gene: MKI67

Class: DEG_SCF_FBW7_1

Location: 1960:1967

E3 ligase: FBXW7

DEGRON score: 0.9775

ASA_SCORE: 90.0875

COIL: 0.8493

CONS_SCORE: 0.4822

DSS_SCORE: 0.6099

HELIX: 0.0628

FCONS_SCORE: 1.1009

RIG_SCORE: 0.6663

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1969K	TCGA-91-6829	LUAD	TCGA	LFQTPGHT	DEG_SCF_FBW7_1	0.2778
p.I1976S	TCGA-BR-8680	STAD	TCGA	LFQTPGHT	DEG_SCF_FBW7_1	0.0833
p.D1953E	TCGA-E6-A1LX	UCEC	TCGA	LFQTPGHT	DEG_SCF_FBW7_1	0.1389
p.T1977N	DO228483	BRCA	ICGC	LFQTPGHT	DEG_SCF_FBW7_1	0.0556
p.T1977N	DO229013	COCA	ICGC	LFQTPGHT	DEG_SCF_FBW7_1	0.0556
p.T1977N	DO229016	COCA	ICGC	LFQTPGHT	DEG_SCF_FBW7_1	0.0556
p.T1972M	DO49929	CESC	ICGC	LFQTPGHT	DEG_SCF_FBW7_1	0.1944
p.T1972M	DO38551	STAD	ICGC	LFQTPGHT	DEG_SCF_FBW7_1	0.1944
p.A1952T	DO222755	COCA	ICGC	LFQTPGHT	DEG_SCF_FBW7_1	0.1111
p.A1952T	DO21487	LAML	ICGC	LFQTPGHT	DEG_SCF_FBW7_1	0.1111
p.D1974H	DO234149	ESAD	ICGC	LFQTPGHT	DEG_SCF_FBW7_1	0.1389
p.D1974H	DO227499	LAML	ICGC	LFQTPGHT	DEG_SCF_FBW7_1	0.1389
p.E1954Q	DO15062	HNSC	ICGC	LFQTPGHT	DEG_SCF_FBW7_1	0.1667
p.P1971T	DO229024	LICA	ICGC	LFQTPGHT	DEG_SCF_FBW7_1	0.2222
p.L1962I	DO229006	LICA	ICGC	LFQTPGHT	DEG_SCF_FBW7_1	0.7174
p.A1950S	DO218935	LUAD	ICGC	LFQTPGHT	DEG_SCF_FBW7_1	0.0556
p.G1958C	DO24656	LUAD	ICGC	LFQTPGHT	DEG_SCF_FBW7_1	0.7222
p.E1961D	DO32247	OV	ICGC	LFQTPGHT	DEG_SCF_FBW7_1	0.6758
p.L1951I	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	LFQTPGHT	DEG_SCF_FBW7_1	0.0833
p.L1951I	SIDM00720	Mesothelioma	GDSC	LFQTPGHT	DEG_SCF_FBW7_1	0.0833
p.L1951I	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	LFQTPGHT	DEG_SCF_FBW7_1	0.0833
p.L1951I	SIDM01752	Pancreatic Carcinoma	GDSC	LFQTPGHT	DEG_SCF_FBW7_1	0.0833
p.T1977I	SIDM01045	Endometrial Carcinoma	GDSC	LFQTPGHT	DEG_SCF_FBW7_1	0.0556
p.T1977I	ACH-000978	Endometrial/Uterine Cancer	CCLE	LFQTPGHT	DEG_SCF_FBW7_1	0.0556
p.T1977I	EN	endometrium	COSMIC	LFQTPGHT	DEG_SCF_FBW7_1	0.0556
p.E1968D	SIDM00493	Other Solid Cancers	GDSC	LFQTPGHT	DEG_SCF_FBW7_1	0.3056
p.E1968D	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	LFQTPGHT	DEG_SCF_FBW7_1	0.3056
p.D1973N	SIDM00118	Colorectal Carcinoma	GDSC	LFQTPGHT	DEG_SCF_FBW7_1	0.1667
p.D1973N	ACH-001081	Colon/Colorectal Cancer	CCLE	LFQTPGHT	DEG_SCF_FBW7_1	0.1667
p.D1973N	HCC2998	large_intestine	COSMIC	LFQTPGHT	DEG_SCF_FBW7_1	0.1667
p.G1958D	HT	haematopoietic_and_lymphoid_tissue	COSMIC	LFQTPGHT	DEG_SCF_FBW7_1	0.7222
p.F1963L	NCI-H630	large_intestine	COSMIC	LFQTPGHT	DEG_SCF_FBW7_1	0.6981

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LFQTPGHT

Degron related mutations and impact score

Drug responses associated with MKI67 mutations

All proteins holding degron of LFQTPGHT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P46013	Proliferation marker protein Ki-67	DEG_SCF_FBW7_1	1230:1237	LFQTPGHT	FBXW7	0.9924	More...
P46013	Proliferation marker protein Ki-67	DEG_SCF_FBW7_1	1352:1359	LFQTPGHT	FBXW7	0.9911	More...
P46013	Proliferation marker protein Ki-67	DEG_SCF_FBW7_1	1960:1967	LFQTPGHT	FBXW7	0.9775	More...
P46013	Proliferation marker protein Ki-67	DEG_SCF_FBW7_1	2443:2450	LFQTPGHT	FBXW7	0.9018	More...