DegronMD

Uniprot ID: P46013

Source protein: Proliferation marker protein Ki-67

Source gene: MKI67

Class: DEG_SCF_FBW7_1

Location: 1960:1967

E3 ligase: FBXW7

DEGRON score: 0.9775

ASA_SCORE: 90.0875

COIL: 0.8493

CONS_SCORE: 0.4822

DSS_SCORE: 0.6099

HELIX: 0.0628

FCONS_SCORE: 1.1009

RIG_SCORE: 0.6663

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1958C	DO24656	LUAD	ICGC	LFQTPGHT	DEG_SCF_FBW7_1	0.7222
p.G1958D	HT	haematopoietic_and_lymphoid_tissue	COSMIC	LFQTPGHT	DEG_SCF_FBW7_1	0.7222
p.L1962I	DO229006	LICA	ICGC	LFQTPGHT	DEG_SCF_FBW7_1	0.7174
p.F1963L	NCI-H630	large_intestine	COSMIC	LFQTPGHT	DEG_SCF_FBW7_1	0.6981
p.E1961D	DO32247	OV	ICGC	LFQTPGHT	DEG_SCF_FBW7_1	0.6758
p.E1968D	SIDM00493	Other Solid Cancers	GDSC	LFQTPGHT	DEG_SCF_FBW7_1	0.3056
p.E1968D	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	LFQTPGHT	DEG_SCF_FBW7_1	0.3056
p.E1969K	TCGA-91-6829	LUAD	TCGA	LFQTPGHT	DEG_SCF_FBW7_1	0.2778
p.P1971T	DO229024	LICA	ICGC	LFQTPGHT	DEG_SCF_FBW7_1	0.2222
p.T1972M	DO49929	CESC	ICGC	LFQTPGHT	DEG_SCF_FBW7_1	0.1944
p.T1972M	DO38551	STAD	ICGC	LFQTPGHT	DEG_SCF_FBW7_1	0.1944
p.E1954Q	DO15062	HNSC	ICGC	LFQTPGHT	DEG_SCF_FBW7_1	0.1667
p.D1973N	SIDM00118	Colorectal Carcinoma	GDSC	LFQTPGHT	DEG_SCF_FBW7_1	0.1667
p.D1973N	ACH-001081	Colon/Colorectal Cancer	CCLE	LFQTPGHT	DEG_SCF_FBW7_1	0.1667
p.D1973N	HCC2998	large_intestine	COSMIC	LFQTPGHT	DEG_SCF_FBW7_1	0.1667
p.D1953E	TCGA-E6-A1LX	UCEC	TCGA	LFQTPGHT	DEG_SCF_FBW7_1	0.1389
p.D1974H	DO234149	ESAD	ICGC	LFQTPGHT	DEG_SCF_FBW7_1	0.1389
p.D1974H	DO227499	LAML	ICGC	LFQTPGHT	DEG_SCF_FBW7_1	0.1389
p.A1952T	DO222755	COCA	ICGC	LFQTPGHT	DEG_SCF_FBW7_1	0.1111
p.A1952T	DO21487	LAML	ICGC	LFQTPGHT	DEG_SCF_FBW7_1	0.1111
p.I1976S	TCGA-BR-8680	STAD	TCGA	LFQTPGHT	DEG_SCF_FBW7_1	0.0833
p.L1951I	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	LFQTPGHT	DEG_SCF_FBW7_1	0.0833
p.L1951I	SIDM00720	Mesothelioma	GDSC	LFQTPGHT	DEG_SCF_FBW7_1	0.0833
p.L1951I	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	LFQTPGHT	DEG_SCF_FBW7_1	0.0833
p.L1951I	SIDM01752	Pancreatic Carcinoma	GDSC	LFQTPGHT	DEG_SCF_FBW7_1	0.0833

Showing 1 to 25 of 32 entries

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Drug responses associated with MKI67 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of LFQTPGHT

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P46013	Proliferation marker protein Ki-67	DEG_SCF_FBW7_1	1230:1237	LFQTPGHT	FBXW7	0.9924	More...
P46013	Proliferation marker protein Ki-67	DEG_SCF_FBW7_1	1352:1359	LFQTPGHT	FBXW7	0.9911	More...
P46013	Proliferation marker protein Ki-67	DEG_SCF_FBW7_1	1960:1967	LFQTPGHT	FBXW7	0.9775	More...
P46013	Proliferation marker protein Ki-67	DEG_SCF_FBW7_1	2443:2450	LFQTPGHT	FBXW7	0.9018	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LFQTPGHT

Degron related mutations and impact score

Drug responses associated with MKI67 mutations

All proteins holding degron of LFQTPGHT