DegronMD

Uniprot ID: P46013

Source protein: Proliferation marker protein Ki-67

Source gene: MKI67

Class: DEG_SCF_FBW7_1

Location: 1296:1302

E3 ligase: FBXW7

DEGRON score: 0.9861

ASA_SCORE: 97.3571

COIL: 0.9153

CONS_SCORE: 0.2552

DSS_SCORE: 0.5791

HELIX: 0.0181

FCONS_SCORE: 0.9695

RIG_SCORE: 0.6643

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1295V	TCGA-AP-A1E1	UCEC	TCGA	MHTPKPS	DEG_SCF_FBW7_1	0.3056
p.D1309H	DO44029	BLCA	ICGC	MHTPKPS	DEG_SCF_FBW7_1	0.1389
p.T1302I	DO50090	COAD	ICGC	MHTPKPS	DEG_SCF_FBW7_1	0.7078
p.T1304R	DO222769	COCA	ICGC	MHTPKPS	DEG_SCF_FBW7_1	0.2778
p.S1312R	DO228948	LICA	ICGC	MHTPKPS	DEG_SCF_FBW7_1	0.0556
p.S1312R	DO229019	LICA	ICGC	MHTPKPS	DEG_SCF_FBW7_1	0.0556
p.T1295I	DO28321	OV	ICGC	MHTPKPS	DEG_SCF_FBW7_1	0.3056
p.D1309N	DO229456	SKCA	ICGC	MHTPKPS	DEG_SCF_FBW7_1	0.1389
p.S1312I	DO40884	UCEC	ICGC	MHTPKPS	DEG_SCF_FBW7_1	0.0556
p.T1298M	SIDM00660	Colorectal Carcinoma	GDSC	MHTPKPS	DEG_SCF_FBW7_1	0.8534
p.T1298M	LS-411N	large_intestine	COSMIC	MHTPKPS	DEG_SCF_FBW7_1	0.8534
p.T1295K	HuH-7	liver	COSMIC	MHTPKPS	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P46013	Proliferation marker protein Ki-67	DEG_SCF_FBW7_1	1296:1302	MHTPKPS	FBXW7	0.9861	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons