DegronMD

Uniprot ID: P46013

Source protein: Proliferation marker protein Ki-67

Source gene: MKI67

Class: LIG_APCC_ABBAyCdc20_2

Location: 513:519

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9982

ASA_SCORE: 101.2

COIL: 0.7163

CONS_SCORE: 0.9118

DSS_SCORE: 0.5178

HELIX: 0.2771

FCONS_SCORE: 1.0172

RIG_SCORE: 0.726

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S507F	TCGA-22-5473	LUSC	TCGA	RPELFDE	LIG_APCC_ABBAyCdc20_2	0.6111
p.S507F	TCGA-YD-A89C	SKCM	TCGA	RPELFDE	LIG_APCC_ABBAyCdc20_2	0.6111
p.P526S	TCGA-A5-A0VP	UCEC	TCGA	RPELFDE	LIG_APCC_ABBAyCdc20_2	0.1389
p.R505H	TCGA-AP-A051	UCEC	TCGA	RPELFDE	LIG_APCC_ABBAyCdc20_2	0.1111
p.R505H	SIDM00837	Colorectal Carcinoma	GDSC	RPELFDE	LIG_APCC_ABBAyCdc20_2	0.1111
p.R505H	SW48	large_intestine	COSMIC	RPELFDE	LIG_APCC_ABBAyCdc20_2	0.1111
p.R503I	TCGA-AP-A1DV	UCEC	TCGA	RPELFDE	LIG_APCC_ABBAyCdc20_2	0.0556
p.R503I	TCGA-EO-A3B0	UCEC	TCGA	RPELFDE	LIG_APCC_ABBAyCdc20_2	0.0556
p.P523A	TCGA-B0-4706	KIRC	TCGA	RPELFDE	LIG_APCC_ABBAyCdc20_2	0.2222
p.R529S	TCGA-D3-A2JP	SKCM	TCGA	RPELFDE	LIG_APCC_ABBAyCdc20_2	0.0556
p.R513I	TCGA-EY-A1GI	UCEC	TCGA	RPELFDE	LIG_APCC_ABBAyCdc20_2	0.8102
p.D518H	TCGA-GM-A2D9	BRCA	TCGA	RPELFDE	LIG_APCC_ABBAyCdc20_2	0.6577
p.D518N	TCGA-XF-A9T8	BLCA	TCGA	RPELFDE	LIG_APCC_ABBAyCdc20_2	0.5821
p.S506L	DO51632	CESC	ICGC	RPELFDE	LIG_APCC_ABBAyCdc20_2	0.1389
p.S510P	DO9876	COAD	ICGC	RPELFDE	LIG_APCC_ABBAyCdc20_2	0.25
p.T503A	DO222884	COCA	ICGC	RPELFDE	LIG_APCC_ABBAyCdc20_2	0.0556
p.V529M	DO26423	LUSC	ICGC	RPELFDE	LIG_APCC_ABBAyCdc20_2	0.0556
p.Q525H	DO219161	LUSC	ICGC	RPELFDE	LIG_APCC_ABBAyCdc20_2	0.6111
p.T525M	SIDM00846	Cervical Carcinoma	GDSC	RPELFDE	LIG_APCC_ABBAyCdc20_2	0.6111
p.T525M	HeLa	cervix	COSMIC	RPELFDE	LIG_APCC_ABBAyCdc20_2	0.6111
p.G510V	ACH-000887	Brain Cancer	CCLE	RPELFDE	LIG_APCC_ABBAyCdc20_2	0.25
p.E520D	KYSE-270	oesophagus	COSMIC	RPELFDE	LIG_APCC_ABBAyCdc20_2	0.3056
p.P528H	639-V	urinary_tract	COSMIC	RPELFDE	LIG_APCC_ABBAyCdc20_2	0.5278
p.E504D	NCI-H1155	lung	COSMIC	RPELFDE	LIG_APCC_ABBAyCdc20_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P46013	Proliferation marker protein Ki-67	LIG_APCC_ABBAyCdc20_2	513:519	RPELFDE	APC,CDC20,FZR1	0.9982	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RPELFDE

Degron related mutations and impact score

Drug responses associated with MKI67 mutations

All proteins holding degron of RPELFDE