DegronMD

Uniprot ID: P46013

Source protein: Proliferation marker protein Ki-67

Source gene: MKI67

Class: LIG_APCC_ABBA_1

Location: 2157:2162

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.978

ASA_SCORE: 104.15

COIL: 0.8083

CONS_SCORE: 0.3135

DSS_SCORE: 0.5954

HELIX: 0.0348

FCONS_SCORE: 0.8772

RIG_SCORE: 0.7902

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D2169N	TCGA-A7-A6VX	BRCA	TCGA	INVFRE	LIG_APCC_ABBA_1	0.1389
p.N2158T	TCGA-D8-A1XQ	BRCA	TCGA	INVFRE	LIG_APCC_ABBA_1	0.5944
p.A2164T	TCGA-GN-A8LN	SKCM	TCGA	INVFRE	LIG_APCC_ABBA_1	0.2778
p.R2161K	TCGA-L5-A8NK	ESCA	TCGA	INVFRE	LIG_APCC_ABBA_1	0.6126
p.F2165C	DO48566	BLCA	ICGC	INVFRE	LIG_APCC_ABBA_1	0.3611
p.K2163N	DO50104	LUSC	ICGC	INVFRE	LIG_APCC_ABBA_1	0.3056
p.T2148N	DO42568	UCEC	ICGC	INVFRE	LIG_APCC_ABBA_1	0.1944
p.A2164V	SIDM00145	T-Lymphoblastic Leukemia	GDSC	INVFRE	LIG_APCC_ABBA_1	0.2778
p.A2164V	ACH-001127	Leukemia	CCLE	INVFRE	LIG_APCC_ABBA_1	0.2778
p.A2164V	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	INVFRE	LIG_APCC_ABBA_1	0.2778
p.E2167D	HCT-116	large_intestine	COSMIC	INVFRE	LIG_APCC_ABBA_1	0.6389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P46013	Proliferation marker protein Ki-67	LIG_APCC_ABBA_1	2157:2162	INVFRE	APC,CDC20,FZR1	0.978	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons