DegronMD

Uniprot ID: P46013

Source protein: Proliferation marker protein Ki-67

Source gene: MKI67

Class: DEG_SCF_FBW7_1

Location: 2924:2931

E3 ligase: FBXW7

DEGRON score: 0.7934

ASA_SCORE: 85.625

COIL: 0.8853

CONS_SCORE: 0.3693

DSS_SCORE: 0.6719

HELIX: 0.051

FCONS_SCORE: 0.9834

RIG_SCORE: 0.6146

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T2927A	SIDM00217	Colorectal Carcinoma	GDSC	LSQTPGHT	DEG_SCF_FBW7_1	0.825
p.T2927A	ACH-000999	Colon/Colorectal Cancer	CCLE	LSQTPGHT	DEG_SCF_FBW7_1	0.825
p.T2927A	SNU-1040	large_intestine	COSMIC	LSQTPGHT	DEG_SCF_FBW7_1	0.825
p.Q2926K	SIDM01265	Plasma Cell Myeloma	GDSC	LSQTPGHT	DEG_SCF_FBW7_1	0.5833
p.Q2926K	SIDM00633	Breast Carcinoma	GDSC	LSQTPGHT	DEG_SCF_FBW7_1	0.5833
p.Q2926K	SIDM01099	Neuroblastoma	GDSC	LSQTPGHT	DEG_SCF_FBW7_1	0.5833
p.Q2926K	SIDM00928	Breast Carcinoma	GDSC	LSQTPGHT	DEG_SCF_FBW7_1	0.5833
p.Q2926K	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	LSQTPGHT	DEG_SCF_FBW7_1	0.5833
p.Q2926K	SIDM00971	Breast Carcinoma	GDSC	LSQTPGHT	DEG_SCF_FBW7_1	0.5833
p.Q2926K	SIDM00930	Osteosarcoma	GDSC	LSQTPGHT	DEG_SCF_FBW7_1	0.5833
p.Q2926K	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	LSQTPGHT	DEG_SCF_FBW7_1	0.5833
p.L2918P	SIDM01588	Endometrial Carcinoma	GDSC	LSQTPGHT	DEG_SCF_FBW7_1	0.1667
p.L2918P	ACH-000993	Endometrial/Uterine Cancer	CCLE	LSQTPGHT	DEG_SCF_FBW7_1	0.1667
p.D2940N	SIDM00794	Other Solid Cancers	GDSC	LSQTPGHT	DEG_SCF_FBW7_1	0.0833
p.D2940N	ACH-000975	Lung Cancer	CCLE	LSQTPGHT	DEG_SCF_FBW7_1	0.0833
p.D2940N	ACH-001442	Skin Cancer	CCLE	LSQTPGHT	DEG_SCF_FBW7_1	0.0833
p.D2940N	A388	skin	COSMIC	LSQTPGHT	DEG_SCF_FBW7_1	0.0833

Showing 1 to 17 of 17 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P46013	Proliferation marker protein Ki-67	DEG_SCF_FBW7_1	2924:2931	LSQTPGHT	FBXW7	0.7934	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons