DegronMD: protein-targeted degradation, mutation and drug response to degrons
Home
(current)
Browse
Proteins/Degrons
Mutations
Drug response
Network-rewiring
Drug resistance
Search
Tutorial
Download
Contact
Links
BSML
CPH
CGC
Degron:
LSQTPGHT
Uniprot ID:
P46013
Source protein:
Proliferation marker protein Ki-67
Source gene:
MKI67
Class:
DEG_SCF_FBW7_1
Location:
2924:2931
E3 ligase:
FBXW7
DEGRON score:
0.7934
ASA_SCORE:
85.625
COIL:
0.8853
CONS_SCORE:
0.3693
DSS_SCORE:
0.6719
HELIX:
0.051
FCONS_SCORE:
0.9834
RIG_SCORE:
0.6146
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.Q2926K
SIDM01265
Plasma Cell Myeloma
GDSC
LSQTPGHT
DEG_SCF_FBW7_1
0.5833
p.Q2926K
SIDM00633
Breast Carcinoma
GDSC
LSQTPGHT
DEG_SCF_FBW7_1
0.5833
p.Q2926K
SIDM01099
Neuroblastoma
GDSC
LSQTPGHT
DEG_SCF_FBW7_1
0.5833
p.Q2926K
SIDM00928
Breast Carcinoma
GDSC
LSQTPGHT
DEG_SCF_FBW7_1
0.5833
p.Q2926K
SIDM00052
Esophageal Squamous Cell Carcinoma
GDSC
LSQTPGHT
DEG_SCF_FBW7_1
0.5833
p.Q2926K
SIDM00971
Breast Carcinoma
GDSC
LSQTPGHT
DEG_SCF_FBW7_1
0.5833
p.Q2926K
SIDM00930
Osteosarcoma
GDSC
LSQTPGHT
DEG_SCF_FBW7_1
0.5833
p.Q2926K
SIDM00956
Esophageal Squamous Cell Carcinoma
GDSC
LSQTPGHT
DEG_SCF_FBW7_1
0.5833
p.D2940N
SIDM00794
Other Solid Cancers
GDSC
LSQTPGHT
DEG_SCF_FBW7_1
0.0833
p.D2940N
ACH-000975
Lung Cancer
CCLE
LSQTPGHT
DEG_SCF_FBW7_1
0.0833
p.D2940N
ACH-001442
Skin Cancer
CCLE
LSQTPGHT
DEG_SCF_FBW7_1
0.0833
p.D2940N
A388
skin
COSMIC
LSQTPGHT
DEG_SCF_FBW7_1
0.0833
p.T2927A
SIDM00217
Colorectal Carcinoma
GDSC
LSQTPGHT
DEG_SCF_FBW7_1
0.825
p.T2927A
ACH-000999
Colon/Colorectal Cancer
CCLE
LSQTPGHT
DEG_SCF_FBW7_1
0.825
p.T2927A
SNU-1040
large_intestine
COSMIC
LSQTPGHT
DEG_SCF_FBW7_1
0.825
p.L2918P
SIDM01588
Endometrial Carcinoma
GDSC
LSQTPGHT
DEG_SCF_FBW7_1
0.1667
p.L2918P
ACH-000993
Endometrial/Uterine Cancer
CCLE
LSQTPGHT
DEG_SCF_FBW7_1
0.1667
Drug responses associated with MKI67 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LSQTPGHT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P46013
Proliferation marker protein Ki-67
DEG_SCF_FBW7_1
2924:2931
LSQTPGHT
FBXW7
0.7934
More...