DegronMD

Uniprot ID: P46013

Source protein: Proliferation marker protein Ki-67

Source gene: MKI67

Class: DEG_SCF_FBW7_1

Location: 1744:1751

E3 ligase: FBXW7

DEGRON score: 0.9413

ASA_SCORE: 88.525

COIL: 0.9116

CONS_SCORE: 0.3635

DSS_SCORE: 0.7256

HELIX: 0.0195

FCONS_SCORE: 0.967

RIG_SCORE: 0.6398

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Y1737D	TCGA-17-Z004	LUAD	TCGA	LVDTPTSS	DEG_SCF_FBW7_1	0.5833
p.R1738I	TCGA-AP-A059	UCEC	TCGA	LVDTPTSS	DEG_SCF_FBW7_1	0.1667
p.L1759I	TCGA-AX-A2HC	UCEC	TCGA	LVDTPTSS	DEG_SCF_FBW7_1	0.1111
p.S1750R	TCGA-B5-A11E	UCEC	TCGA	LVDTPTSS	DEG_SCF_FBW7_1	0.7427
p.R1760W	DO225396	BRCA	ICGC	LVDTPTSS	DEG_SCF_FBW7_1	0.0833
p.R1760W	DO43186	UCEC	ICGC	LVDTPTSS	DEG_SCF_FBW7_1	0.0833
p.I1741T	DO229010	COCA	ICGC	LVDTPTSS	DEG_SCF_FBW7_1	0.25
p.I1741T	DO234285	ESAD	ICGC	LVDTPTSS	DEG_SCF_FBW7_1	0.25
p.I1741T	DO230659	LAML	ICGC	LVDTPTSS	DEG_SCF_FBW7_1	0.25
p.I1741T	DO231140	LAML	ICGC	LVDTPTSS	DEG_SCF_FBW7_1	0.25
p.I1741T	DO228947	LICA	ICGC	LVDTPTSS	DEG_SCF_FBW7_1	0.25
p.I1741T	DO229047	LICA	ICGC	LVDTPTSS	DEG_SCF_FBW7_1	0.25
p.I1741T	DO230993	LUSC	ICGC	LVDTPTSS	DEG_SCF_FBW7_1	0.25
p.S1756N	DO223038	ESCA	ICGC	LVDTPTSS	DEG_SCF_FBW7_1	0.3056
p.T1739N	DO228986	LICA	ICGC	LVDTPTSS	DEG_SCF_FBW7_1	0.1944
p.T1755K	DO229006	LICA	ICGC	LVDTPTSS	DEG_SCF_FBW7_1	0.2222
p.K1740E	DO23610	LUAD	ICGC	LVDTPTSS	DEG_SCF_FBW7_1	0.6667
p.A1742V	DO26512	LUSC	ICGC	LVDTPTSS	DEG_SCF_FBW7_1	0.2778
p.K1737R	DO26419	LUSC	ICGC	LVDTPTSS	DEG_SCF_FBW7_1	0.5833
p.A1742S	DO45452	LUSC	ICGC	LVDTPTSS	DEG_SCF_FBW7_1	0.2778
p.P1754S	DO218864	SKCA	ICGC	LVDTPTSS	DEG_SCF_FBW7_1	0.25
p.P1746S	DO50299	SKCM	ICGC	LVDTPTSS	DEG_SCF_FBW7_1	0.6752
p.M1751V	DO38619	STAD	ICGC	LVDTPTSS	DEG_SCF_FBW7_1	0.7208
p.P1748S	DO42312	UCEC	ICGC	LVDTPTSS	DEG_SCF_FBW7_1	0.6752
p.S1750N	SIDM00369	Esophageal Squamous Cell Carcinoma	GDSC	LVDTPTSS	DEG_SCF_FBW7_1	0.7069
p.S1750N	ACH-000647	Esophageal Cancer	CCLE	LVDTPTSS	DEG_SCF_FBW7_1	0.7069
p.S1750N	TE-1	oesophagus	COSMIC	LVDTPTSS	DEG_SCF_FBW7_1	0.7069
p.L1744P	SIDM01045	Endometrial Carcinoma	GDSC	LVDTPTSS	DEG_SCF_FBW7_1	0.6471
p.L1744P	ACH-000978	Endometrial/Uterine Cancer	CCLE	LVDTPTSS	DEG_SCF_FBW7_1	0.6471
p.L1744P	EN	endometrium	COSMIC	LVDTPTSS	DEG_SCF_FBW7_1	0.6471
p.T1757I	LAN-6	autonomic_ganglia	COSMIC	LVDTPTSS	DEG_SCF_FBW7_1	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LVDTPTSS

Degron related mutations and impact score

Drug responses associated with MKI67 mutations

All proteins holding degron of LVDTPTSS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P46013	Proliferation marker protein Ki-67	DEG_SCF_FBW7_1	1744:1751	LVDTPTSS	FBXW7	0.9413	More...