DegronMD

Uniprot ID: P46013

Source protein: Proliferation marker protein Ki-67

Source gene: MKI67

Class: DEG_SCF_FBW7_1

Location: 2082:2089

E3 ligase: FBXW7

DEGRON score: 0.9865

ASA_SCORE: 102.125

COIL: 0.9078

CONS_SCORE: 0.3981

DSS_SCORE: 0.6648

HELIX: 0.0417

FCONS_SCORE: 1.1336

RIG_SCORE: 0.6741

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K2097R	TCGA-66-2786	LUSC	TCGA	LFQTPDHT	DEG_SCF_FBW7_1	0.2222
p.E2090D	TCGA-A5-A0G1	UCEC	TCGA	LFQTPDHT	DEG_SCF_FBW7_1	0.3056
p.T2089I	TCGA-AP-A1DR	UCEC	TCGA	LFQTPDHT	DEG_SCF_FBW7_1	0.8189
p.Q2084H	TCGA-ER-A2NG	SKCM	TCGA	LFQTPDHT	DEG_SCF_FBW7_1	0.647
p.E2090K	TCGA-IR-A3LI	CESC	TCGA	LFQTPDHT	DEG_SCF_FBW7_1	0.3056
p.E2082K	DO218136	GACA	ICGC	LFQTPDHT	DEG_SCF_FBW7_1	0.7022
p.D2076G	DO22189	LGG	ICGC	LFQTPDHT	DEG_SCF_FBW7_1	0.1667
p.E2072Q	DO45428	LUSC	ICGC	LFQTPDHT	DEG_SCF_FBW7_1	0.5
p.E2075D	DO41235	UCEC	ICGC	LFQTPDHT	DEG_SCF_FBW7_1	0.1389
p.L2073I	SIDM00649	Non-Small Cell Lung Carcinoma	GDSC	LFQTPDHT	DEG_SCF_FBW7_1	0.0833
p.Q2084R	SIDM00583	Pancreatic Carcinoma	GDSC	LFQTPDHT	DEG_SCF_FBW7_1	0.6218
p.Q2084R	ACH-001107	Pancreatic Cancer	CCLE	LFQTPDHT	DEG_SCF_FBW7_1	0.6218
p.Q2084R	KP-1N	pancreas	COSMIC	LFQTPDHT	DEG_SCF_FBW7_1	0.6218
p.T2093I	SIDM01134	Small Cell Lung Carcinoma	GDSC	LFQTPDHT	DEG_SCF_FBW7_1	0.2222
p.T2093I	SIDM01591	Breast Carcinoma	GDSC	LFQTPDHT	DEG_SCF_FBW7_1	0.2222
p.T2093I	ACH-000292	Lung Cancer	CCLE	LFQTPDHT	DEG_SCF_FBW7_1	0.2222
p.T2093I	ACH-000540	Non-Cancerous	CCLE	LFQTPDHT	DEG_SCF_FBW7_1	0.2222
p.T2093I	NCI-H841	lung	COSMIC	LFQTPDHT	DEG_SCF_FBW7_1	0.2222
p.G2078A	ACH-000690	Lung Cancer	CCLE	LFQTPDHT	DEG_SCF_FBW7_1	0.2222
p.G2088D	KURAMOCHI	ovary	COSMIC	LFQTPDHT	DEG_SCF_FBW7_1	0.7198
p.K2081E	HCC1569	breast	COSMIC	LFQTPDHT	DEG_SCF_FBW7_1	0.3056
p.S2093L	A431	skin	COSMIC	LFQTPDHT	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P46013	Proliferation marker protein Ki-67	DEG_SCF_FBW7_1	2082:2089	LFQTPDHT	FBXW7	0.9865	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons