DegronMD

Uniprot ID: P46013

Source protein: Proliferation marker protein Ki-67

Source gene: MKI67

Class: DEG_APCC_KENBOX_2

Location: 932:936

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9435

ASA_SCORE: 116.92

COIL: 0.8662

CONS_SCORE: 0.2883

DSS_SCORE: 0.4332

HELIX: 0.0604

FCONS_SCORE: 0.8937

RIG_SCORE: 0.7996

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E930D	TCGA-AP-A056	UCEC	TCGA	YKENI	DEG_APCC_KENBOX_2	0.2778
p.N935T	TCGA-AX-A06F	UCEC	TCGA	YKENI	DEG_APCC_KENBOX_2	0.7055
p.K944N	TCGA-AX-A2HC	UCEC	TCGA	YKENI	DEG_APCC_KENBOX_2	0.2222
p.E924K	TCGA-BB-A5HY	HNSC	TCGA	YKENI	DEG_APCC_KENBOX_2	0.1111
p.T931I	TCGA-F1-6874	STAD	TCGA	YKENI	DEG_APCC_KENBOX_2	0.3056
p.E930K	TCGA-XF-AAN0	BLCA	TCGA	YKENI	DEG_APCC_KENBOX_2	0.2778
p.A924E	DO35192	PACA	ICGC	YKENI	DEG_APCC_KENBOX_2	0.1111
p.A935V	DO43226	UCEC	ICGC	YKENI	DEG_APCC_KENBOX_2	0.6936
p.L922F	DO41584	UCEC	ICGC	YKENI	DEG_APCC_KENBOX_2	0.0556
p.E926G	ACH-001608	Brain Cancer	CCLE	YKENI	DEG_APCC_KENBOX_2	0.1667
p.Y932F	ACH-002061	Leukemia	CCLE	YKENI	DEG_APCC_KENBOX_2	0.6417

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P46013	Proliferation marker protein Ki-67	DEG_APCC_KENBOX_2	932:936	YKENI	APC,CDC20,FZR1	0.9435	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons