DegronMD

Uniprot ID: P46013

Source protein: Proliferation marker protein Ki-67

Source gene: MKI67

Class: DEG_SCF_FBW7_2

Location: 2063:2069

E3 ligase: FBXW7

DEGRON score: 0.9993

ASA_SCORE: 120.7286

COIL: 0.9253

CONS_SCORE: 0.4215

DSS_SCORE: 0.6503

HELIX: 0.0479

FCONS_SCORE: 1.2746

RIG_SCORE: 0.7143

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P2066A	TCGA-78-8640	LUAD	TCGA	PRTPKEE	DEG_SCF_FBW7_2	0.7503
p.N2054D	TCGA-BS-A0UF	UCEC	TCGA	PRTPKEE	DEG_SCF_FBW7_2	0.0833
p.G2058E	TCGA-D9-A1JW	SKCM	TCGA	PRTPKEE	DEG_SCF_FBW7_2	0.1944
p.G2058R	TCGA-D9-A1JW	SKCM	TCGA	PRTPKEE	DEG_SCF_FBW7_2	0.1944
p.E2069Q	TCGA-G2-A2EO	BLCA	TCGA	PRTPKEE	DEG_SCF_FBW7_2	0.6744
p.D2076G	DO22189	LGG	ICGC	PRTPKEE	DEG_SCF_FBW7_2	0.1389
p.L2057F	DO228901	LICA	ICGC	PRTPKEE	DEG_SCF_FBW7_2	0.1667
p.E2072Q	DO45428	LUSC	ICGC	PRTPKEE	DEG_SCF_FBW7_2	0.6944
p.E2069D	DO219773	UCEC	ICGC	PRTPKEE	DEG_SCF_FBW7_2	0.6758
p.E2075D	DO41235	UCEC	ICGC	PRTPKEE	DEG_SCF_FBW7_2	0.1667
p.Q2063H	DO41361	UCEC	ICGC	PRTPKEE	DEG_SCF_FBW7_2	0.7582
p.L2073I	SIDM00649	Non-Small Cell Lung Carcinoma	GDSC	PRTPKEE	DEG_SCF_FBW7_2	0.2222
p.T2057S	SIDM00959	Acute Myeloid Leukemia	GDSC	PRTPKEE	DEG_SCF_FBW7_2	0.1667
p.T2057S	ACH-000641	Leukemia	CCLE	PRTPKEE	DEG_SCF_FBW7_2	0.1667
p.T2057S	ACH-001036	Leukemia	CCLE	PRTPKEE	DEG_SCF_FBW7_2	0.1667
p.T2057S	CMK	haematopoietic_and_lymphoid_tissue	COSMIC	PRTPKEE	DEG_SCF_FBW7_2	0.1667
p.G2078A	ACH-000690	Lung Cancer	CCLE	PRTPKEE	DEG_SCF_FBW7_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P46013	Proliferation marker protein Ki-67	DEG_SCF_FBW7_2	1089:1095	PRTPKEE	FBXW7	0.9891	More...
P46013	Proliferation marker protein Ki-67	DEG_SCF_FBW7_2	2063:2069	PRTPKEE	FBXW7	0.9993	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons