DegronMD

Uniprot ID: P46013

Source protein: Proliferation marker protein Ki-67

Source gene: MKI67

Class: DEG_SCF_FBW7_2

Location: 1089:1095

E3 ligase: FBXW7

DEGRON score: 0.9891

ASA_SCORE: 119.9

COIL: 0.923

CONS_SCORE: 0.2776

DSS_SCORE: 0.6042

HELIX: 0.0481

FCONS_SCORE: 0.9266

RIG_SCORE: 0.7175

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1081H	TCGA-A5-A1OF	UCEC	TCGA	PRTPKEE	DEG_SCF_FBW7_2	0.1111
p.R1090T	TCGA-D6-A6EQ	HNSC	TCGA	PRTPKEE	DEG_SCF_FBW7_2	0.6765
p.G1104A	TCGA-E8-A417	THCA	TCGA	PRTPKEE	DEG_SCF_FBW7_2	0.0833
p.E1094Q	TCGA-FD-A6TC	BLCA	TCGA	PRTPKEE	DEG_SCF_FBW7_2	0.5633
p.K1100R	DO7828	COAD	ICGC	PRTPKEE	DEG_SCF_FBW7_2	0.1944
p.H1094Q	DO219217	LUSC	ICGC	PRTPKEE	DEG_SCF_FBW7_2	0.7582
p.E1105Q	DO27540	LUSC	ICGC	PRTPKEE	DEG_SCF_FBW7_2	0.0556
p.K1096Q	DO36556	READ	ICGC	PRTPKEE	DEG_SCF_FBW7_2	0.3056
p.P1103L	DO37406	SKCM	ICGC	PRTPKEE	DEG_SCF_FBW7_2	0.1111
p.K1079N	DO223282	UCEC	ICGC	PRTPKEE	DEG_SCF_FBW7_2	0.0556
p.T1091M	SIDM00649	Non-Small Cell Lung Carcinoma	GDSC	PRTPKEE	DEG_SCF_FBW7_2	0.8534
p.M1085K	SIDM00607	Glioblastoma	GDSC	PRTPKEE	DEG_SCF_FBW7_2	0.2222
p.M1085K	SIDM00530	Esophageal Carcinoma	GDSC	PRTPKEE	DEG_SCF_FBW7_2	0.2222
p.M1085K	KYAE-1	oesophagus	COSMIC	PRTPKEE	DEG_SCF_FBW7_2	0.2222
p.M1085T	SIDM00231	Kidney Carcinoma	GDSC	PRTPKEE	DEG_SCF_FBW7_2	0.2222
p.M1085T	ACH-002167	Kidney Cancer	CCLE	PRTPKEE	DEG_SCF_FBW7_2	0.2222
p.M1085T	NCC010	kidney	COSMIC	PRTPKEE	DEG_SCF_FBW7_2	0.2222
p.K1086N	SIDM00417	Plasma Cell Myeloma	GDSC	PRTPKEE	DEG_SCF_FBW7_2	0.3611
p.K1086N	SIDM00526	Chronic Myelogenous Leukemia	GDSC	PRTPKEE	DEG_SCF_FBW7_2	0.3611
p.K1086N	ACH-000626	Myeloma	CCLE	PRTPKEE	DEG_SCF_FBW7_2	0.3611
p.K1086N	U-266	haematopoietic_and_lymphoid_tissue	COSMIC	PRTPKEE	DEG_SCF_FBW7_2	0.3611
p.K1086N	MEG-01	haematopoietic_and_lymphoid_tissue	COSMIC	PRTPKEE	DEG_SCF_FBW7_2	0.3611
p.P1089S	SIDM00498	Colorectal Carcinoma	GDSC	PRTPKEE	DEG_SCF_FBW7_2	0.6752
p.P1089S	SNU-C5	large_intestine	COSMIC	PRTPKEE	DEG_SCF_FBW7_2	0.6752
p.K1087R	SIDM00498	Colorectal Carcinoma	GDSC	PRTPKEE	DEG_SCF_FBW7_2	0.2778
p.K1087R	ACH-000970	Colon/Colorectal Cancer	CCLE	PRTPKEE	DEG_SCF_FBW7_2	0.2778
p.K1087R	SNU-C5	large_intestine	COSMIC	PRTPKEE	DEG_SCF_FBW7_2	0.2778
p.A1085T	HCT-15	large_intestine	COSMIC	PRTPKEE	DEG_SCF_FBW7_2	0.2222
p.A1101T	COLO-679	skin	COSMIC	PRTPKEE	DEG_SCF_FBW7_2	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PRTPKEE

Degron related mutations and impact score

Drug responses associated with MKI67 mutations

All proteins holding degron of PRTPKEE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P46013	Proliferation marker protein Ki-67	DEG_SCF_FBW7_2	1089:1095	PRTPKEE	FBXW7	0.9891	More...
P46013	Proliferation marker protein Ki-67	DEG_SCF_FBW7_2	2063:2069	PRTPKEE	FBXW7	0.9993	More...