DegronMD

Uniprot ID: P46013

Source protein: Proliferation marker protein Ki-67

Source gene: MKI67

Class: DEG_SCF_FBW7_1

Location: 2349:2356

E3 ligase: FBXW7

DEGRON score: 0.9968

ASA_SCORE: 88.5875

COIL: 0.9323

CONS_SCORE: 0.3989

DSS_SCORE: 0.7808

HELIX: 0.0211

FCONS_SCORE: 1.1277

RIG_SCORE: 0.6401

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T2356N	DO230525	LUSC	ICGC	PVDTPAST	DEG_SCF_FBW7_1	0.8166
p.K2343T	TCGA-EO-A3AV	UCEC	TCGA	PVDTPAST	DEG_SCF_FBW7_1	0.6111
p.K2343T	DO41211	UCEC	ICGC	PVDTPAST	DEG_SCF_FBW7_1	0.6111
p.K2357N	TCGA-EO-A22R	UCEC	TCGA	PVDTPAST	DEG_SCF_FBW7_1	0.3056
p.E2347K	DO9876	COAD	ICGC	PVDTPAST	DEG_SCF_FBW7_1	0.2778
p.E2347K	DO52402	UCEC	ICGC	PVDTPAST	DEG_SCF_FBW7_1	0.2778
p.A2358T	DO46657	PAAD	ICGC	PVDTPAST	DEG_SCF_FBW7_1	0.2778
p.R2359W	TCGA-DF-A2KU	UCEC	TCGA	PVDTPAST	DEG_SCF_FBW7_1	0.25
p.P2360L	TCGA-AP-A051	UCEC	TCGA	PVDTPAST	DEG_SCF_FBW7_1	0.2222
p.T2360P	DO228483	BRCA	ICGC	PVDTPAST	DEG_SCF_FBW7_1	0.2222
p.T2360P	DO229010	COCA	ICGC	PVDTPAST	DEG_SCF_FBW7_1	0.2222
p.T2360P	DO229013	COCA	ICGC	PVDTPAST	DEG_SCF_FBW7_1	0.2222
p.T2360P	DO229016	COCA	ICGC	PVDTPAST	DEG_SCF_FBW7_1	0.2222
p.T2360P	DO229480	LAML	ICGC	PVDTPAST	DEG_SCF_FBW7_1	0.2222
p.T2360P	DO228941	LICA	ICGC	PVDTPAST	DEG_SCF_FBW7_1	0.2222
p.T2360K	DO229015	LICA	ICGC	PVDTPAST	DEG_SCF_FBW7_1	0.2222
p.R2362K	TCGA-XF-AAMG	BLCA	TCGA	PVDTPAST	DEG_SCF_FBW7_1	0.1667
p.G2339S	SCaBER	urinary_tract	COSMIC	PVDTPAST	DEG_SCF_FBW7_1	0.1667
p.H2363N	DO229035	LICA	ICGC	PVDTPAST	DEG_SCF_FBW7_1	0.1389
p.I2340L	TCGA-AG-A002	READ	TCGA	PVDTPAST	DEG_SCF_FBW7_1	0.0833

Showing 1 to 20 of 20 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P46013	Proliferation marker protein Ki-67	DEG_SCF_FBW7_1	2349:2356	PVDTPAST	FBXW7	0.9968	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons