DegronMD

Uniprot ID: P46013

Source protein: Proliferation marker protein Ki-67

Source gene: MKI67

Class: DEG_SCF_FBW7_1

Location: 2200:2207

E3 ligase: FBXW7

DEGRON score: 0.9596

ASA_SCORE: 94.6625

COIL: 0.8375

CONS_SCORE: 0.3396

DSS_SCORE: 0.5046

HELIX: 0.0459

FCONS_SCORE: 0.912

RIG_SCORE: 0.7679

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L2197V	TCGA-18-3406	LUSC	TCGA	LFQTPICT	DEG_SCF_FBW7_1	0.25
p.T2212A	TCGA-A6-2686	COAD	TCGA	LFQTPICT	DEG_SCF_FBW7_1	0.1944
p.L2197F	TCGA-AP-A1E0	UCEC	TCGA	LFQTPICT	DEG_SCF_FBW7_1	0.25
p.L2197F	ACH-002800	Unknown	CCLE	LFQTPICT	DEG_SCF_FBW7_1	0.25
p.T2211R	TCGA-DX-AB2Z	SARC	TCGA	LFQTPICT	DEG_SCF_FBW7_1	0.6667
p.A2195D	TCGA-EO-A22R	UCEC	TCGA	LFQTPICT	DEG_SCF_FBW7_1	0.1944
p.D2208Y	TCGA-OR-A5JA	ACC	TCGA	LFQTPICT	DEG_SCF_FBW7_1	0.3056
p.E2213K	DO219049	BLCA	ICGC	LFQTPICT	DEG_SCF_FBW7_1	0.1667
p.R2194H	DO8479	COAD	ICGC	LFQTPICT	DEG_SCF_FBW7_1	0.1667
p.R2194H	DO233878	GACA	ICGC	LFQTPICT	DEG_SCF_FBW7_1	0.1667
p.H2211Q	DO229041	LICA	ICGC	LFQTPICT	DEG_SCF_FBW7_1	0.6667
p.D2198Y	DO218937	LUAD	ICGC	LFQTPICT	DEG_SCF_FBW7_1	0.7222
p.H2211Y	DO37406	SKCM	ICGC	LFQTPICT	DEG_SCF_FBW7_1	0.6667
p.S2207L	DO41050	UCEC	ICGC	LFQTPICT	DEG_SCF_FBW7_1	0.7667
p.E2204K	DO41903	UCEC	ICGC	LFQTPICT	DEG_SCF_FBW7_1	0.7022
p.P2204S	SIDM00516	Melanoma	GDSC	LFQTPICT	DEG_SCF_FBW7_1	0.6752
p.P2204S	MZ7-mel	skin	COSMIC	LFQTPICT	DEG_SCF_FBW7_1	0.6752
p.P2204A	SIDM00493	Other Solid Cancers	GDSC	LFQTPICT	DEG_SCF_FBW7_1	0.7503
p.P2204A	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	LFQTPICT	DEG_SCF_FBW7_1	0.7503
p.Q2202H	SIDM01567	Hodgkin's Lymphoma	GDSC	LFQTPICT	DEG_SCF_FBW7_1	0.647
p.Q2202H	ACH-000069	Lymphoma	CCLE	LFQTPICT	DEG_SCF_FBW7_1	0.647
p.I2205V	ACH-000386	Leukemia	CCLE	LFQTPICT	DEG_SCF_FBW7_1	0.5965
p.I2205V	KG-1	haematopoietic_and_lymphoid_tissue	COSMIC	LFQTPICT	DEG_SCF_FBW7_1	0.5965
p.E2199Q	ACH-001411	Bladder Cancer	CCLE	LFQTPICT	DEG_SCF_FBW7_1	0.3056
p.E2214Q	ACH-001864	Bile Duct Cancer	CCLE	LFQTPICT	DEG_SCF_FBW7_1	0.1389
p.L2199M	LoVo	large_intestine	COSMIC	LFQTPICT	DEG_SCF_FBW7_1	0.3056
p.K2192N	WSU-NHL	haematopoietic_and_lymphoid_tissue	COSMIC	LFQTPICT	DEG_SCF_FBW7_1	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LFQTPICT

Degron related mutations and impact score

Drug responses associated with MKI67 mutations

All proteins holding degron of LFQTPICT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P46013	Proliferation marker protein Ki-67	DEG_SCF_FBW7_1	2200:2207	LFQTPICT	FBXW7	0.9596	More...