DegronMD

Uniprot ID: P46013

Source protein: Proliferation marker protein Ki-67

Source gene: MKI67

Class: DEG_SCF_FBW7_1

Location: 1716:1723

E3 ligase: FBXW7

DEGRON score: 0.9899

ASA_SCORE: 93.5375

COIL: 0.868

CONS_SCORE: 0.5816

DSS_SCORE: 0.5428

HELIX: 0.0363

FCONS_SCORE: 1.2714

RIG_SCORE: 0.7206

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q1724H	DO47552	SKCM	ICGC	LFQTPSHT	DEG_SCF_FBW7_1	0.75
p.Q1724R	KP-1N	pancreas	COSMIC	LFQTPSHT	DEG_SCF_FBW7_1	0.75
p.E1715K	TCGA-GD-A2C5	BLCA	TCGA	LFQTPSHT	DEG_SCF_FBW7_1	0.3056
p.E1715K	TCGA-RR-A6KA	GBM	TCGA	LFQTPSHT	DEG_SCF_FBW7_1	0.3056
p.E1715K	SIDM01611	Endometrial Carcinoma	GDSC	LFQTPSHT	DEG_SCF_FBW7_1	0.3056
p.E1715K	ACH-000996	Endometrial/Uterine Cancer	CCLE	LFQTPSHT	DEG_SCF_FBW7_1	0.3056
p.A1710D	DO229019	LICA	ICGC	LFQTPSHT	DEG_SCF_FBW7_1	0.1667
p.T1729I	DO43747	UCEC	ICGC	LFQTPSHT	DEG_SCF_FBW7_1	0.1667
p.E1730K	TCGA-JX-A3PZ	CESC	TCGA	LFQTPSHT	DEG_SCF_FBW7_1	0.1389
p.E1730K	DO44400	CESC	ICGC	LFQTPSHT	DEG_SCF_FBW7_1	0.1389
p.E1709Q	DO456	BLCA	ICGC	LFQTPSHT	DEG_SCF_FBW7_1	0.1389
p.E1730D	DO42472	UCEC	ICGC	LFQTPSHT	DEG_SCF_FBW7_1	0.1389
p.P1707S	SIDM01070	Non-Small Cell Lung Carcinoma	GDSC	LFQTPSHT	DEG_SCF_FBW7_1	0.0833
p.P1707S	ACH-000840	Lung Cancer	CCLE	LFQTPSHT	DEG_SCF_FBW7_1	0.0833
p.P1707S	HCC-366	lung	COSMIC	LFQTPSHT	DEG_SCF_FBW7_1	0.0833
p.T1732S	SIDM00208	Glioblastoma	GDSC	LFQTPSHT	DEG_SCF_FBW7_1	0.0833
p.T1732S	ACH-002229	Brain Cancer	CCLE	LFQTPSHT	DEG_SCF_FBW7_1	0.0833
p.T1732S	D-502MG	central_nervous_system	COSMIC	LFQTPSHT	DEG_SCF_FBW7_1	0.0833
p.P1706H	DO229037	LICA	ICGC	LFQTPSHT	DEG_SCF_FBW7_1	0.0556
p.P1706A	DO45340	LUAD	ICGC	LFQTPSHT	DEG_SCF_FBW7_1	0.0556
p.T1733I	NCI-H841	lung	COSMIC	LFQTPSHT	DEG_SCF_FBW7_1	0.0556

Showing 1 to 21 of 21 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P46013	Proliferation marker protein Ki-67	DEG_SCF_FBW7_1	1716:1723	LFQTPSHT	FBXW7	0.9899	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons