DegronMD

Uniprot ID: P46013

Source protein: Proliferation marker protein Ki-67

Source gene: MKI67

Class: DEG_APCC_DBOX_1

Location: 37:45

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6937

ASA_SCORE: 46.2778

COIL: 0.5536

CONS_SCORE: 0.9535

DSS_SCORE: 0.0676

HELIX: 0.0304

FCONS_SCORE: 1.2853

RIG_SCORE: 0.8811

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I51F	TCGA-56-8626	LUSC	TCGA	IRIQLPVVS	DEG_APCC_DBOX_1	0.1667
p.I51F	DO45506	LUSC	ICGC	IRIQLPVVS	DEG_APCC_DBOX_1	0.1667
p.I37T	TCGA-AJ-A23O	UCEC	TCGA	IRIQLPVVS	DEG_APCC_DBOX_1	0.5966
p.I37T	DO43290	UCEC	ICGC	IRIQLPVVS	DEG_APCC_DBOX_1	0.5966
p.D36E	TCGA-BR-A4CS	STAD	TCGA	IRIQLPVVS	DEG_APCC_DBOX_1	0.3056
p.D36E	DO47965	STAD	ICGC	IRIQLPVVS	DEG_APCC_DBOX_1	0.3056
p.R38H	TCGA-TM-A7C3	LGG	TCGA	IRIQLPVVS	DEG_APCC_DBOX_1	0.8244
p.R38H	DO50222	LGG	ICGC	IRIQLPVVS	DEG_APCC_DBOX_1	0.8244
p.G32D	DO46881	RECA	ICGC	IRIQLPVVS	DEG_APCC_DBOX_1	0.1944
p.F29L	SIDM00728	Non-Small Cell Lung Carcinoma	GDSC	IRIQLPVVS	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P46013	Proliferation marker protein Ki-67	DEG_APCC_DBOX_1	37:45	IRIQLPVVS	APC,CDC20,FZR1	0.6937	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons