DegronMD

Uniprot ID: P46013

Source protein: Proliferation marker protein Ki-67

Source gene: MKI67

Class: DEG_SCF_FBW7_1

Location: 1258:1265

E3 ligase: FBXW7

DEGRON score: 0.9913

ASA_SCORE: 90.0375

COIL: 0.9229

CONS_SCORE: 0.47

DSS_SCORE: 0.7685

HELIX: 0.0221

FCONS_SCORE: 1.2685

RIG_SCORE: 0.6509

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1271K	TCGA-05-4424	LUAD	TCGA	PVDTPTST	DEG_SCF_FBW7_1	0.1667
p.R1268Q	TCGA-AA-3984	COAD	TCGA	PVDTPTST	DEG_SCF_FBW7_1	0.25
p.R1268Q	SIDM00313	Hodgkin's Lymphoma	GDSC	PVDTPTST	DEG_SCF_FBW7_1	0.25
p.R1268Q	ACH-000702	Lymphoma	CCLE	PVDTPTST	DEG_SCF_FBW7_1	0.25
p.R1268Q	L-1236	haematopoietic_and_lymphoid_tissue	COSMIC	PVDTPTST	DEG_SCF_FBW7_1	0.25
p.S1256P	TCGA-AX-A063	UCEC	TCGA	PVDTPTST	DEG_SCF_FBW7_1	0.7222
p.P1250L	TCGA-CM-5861	COAD	TCGA	PVDTPTST	DEG_SCF_FBW7_1	0.1111
p.P1250S	TCGA-D1-A16X	UCEC	TCGA	PVDTPTST	DEG_SCF_FBW7_1	0.1111
p.S1264I	TCGA-ZJ-AAX8	CESC	TCGA	PVDTPTST	DEG_SCF_FBW7_1	0.7341
p.A1254T	DO5521	BRCA	ICGC	PVDTPTST	DEG_SCF_FBW7_1	0.2222
p.N1265K	DO233885	GACA	ICGC	PVDTPTST	DEG_SCF_FBW7_1	0.6918
p.N1265K	DO229041	LICA	ICGC	PVDTPTST	DEG_SCF_FBW7_1	0.6918
p.K1274N	DO14550	HNSC	ICGC	PVDTPTST	DEG_SCF_FBW7_1	0.0833
p.D1248N	DO218995	HNSC	ICGC	PVDTPTST	DEG_SCF_FBW7_1	0.5
p.D1263E	DO229019	LICA	ICGC	PVDTPTST	DEG_SCF_FBW7_1	0.6758
p.D1263E	DO229037	LICA	ICGC	PVDTPTST	DEG_SCF_FBW7_1	0.6758
p.P1260T	DO229038	LICA	ICGC	PVDTPTST	DEG_SCF_FBW7_1	0.7031
p.D1263G	DO36389	READ	ICGC	PVDTPTST	DEG_SCF_FBW7_1	0.7198
p.K1264R	DO42312	UCEC	ICGC	PVDTPTST	DEG_SCF_FBW7_1	0.7237
p.T1275A	DO41903	UCEC	ICGC	PVDTPTST	DEG_SCF_FBW7_1	0.5
p.K1248I	SIDM00689	B-Lymphoblastic Leukemia	GDSC	PVDTPTST	DEG_SCF_FBW7_1	0.5
p.K1248I	ACH-000151	Leukemia	CCLE	PVDTPTST	DEG_SCF_FBW7_1	0.5
p.K1248I	JM1	haematopoietic_and_lymphoid_tissue	COSMIC	PVDTPTST	DEG_SCF_FBW7_1	0.5
p.I1273M	SIDM00631	Breast Carcinoma	GDSC	PVDTPTST	DEG_SCF_FBW7_1	0.1111
p.I1273M	ACH-001358	Breast Cancer	CCLE	PVDTPTST	DEG_SCF_FBW7_1	0.1111
p.I1273M	MDA-MB-330	breast	COSMIC	PVDTPTST	DEG_SCF_FBW7_1	0.1111
p.D1252N	SIDM00487	Colorectal Carcinoma	GDSC	PVDTPTST	DEG_SCF_FBW7_1	0.1667
p.D1252N	ACH-000963	Colon/Colorectal Cancer	CCLE	PVDTPTST	DEG_SCF_FBW7_1	0.1667
p.D1252N	CCK-81	large_intestine	COSMIC	PVDTPTST	DEG_SCF_FBW7_1	0.1667
p.K1256R	H290	pleura	COSMIC	PVDTPTST	DEG_SCF_FBW7_1	0.7222
p.Q1259P	CAL-12T	lung	COSMIC	PVDTPTST	DEG_SCF_FBW7_1	0.7035
p.R1272W	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	PVDTPTST	DEG_SCF_FBW7_1	0.5833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PVDTPTST

Degron related mutations and impact score

Drug responses associated with MKI67 mutations

All proteins holding degron of PVDTPTST

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P46013	Proliferation marker protein Ki-67	DEG_SCF_FBW7_1	1258:1265	PVDTPTST	FBXW7	0.9913	More...