DegronMD

Uniprot ID: P46013

Source protein: Proliferation marker protein Ki-67

Source gene: MKI67

Class: DEG_SCF_FBW7_1

Location: 1988:1995

E3 ligase: FBXW7

DEGRON score: 0.9362

ASA_SCORE: 90.05

COIL: 0.904

CONS_SCORE: 0.4347

DSS_SCORE: 0.6479

HELIX: 0.0241

FCONS_SCORE: 1.0968

RIG_SCORE: 0.6706

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.C1981Y	TCGA-F1-6874	STAD	TCGA	PVKTPTSS	DEG_SCF_FBW7_1	0.1389
p.K2000N	TCGA-GV-A3JX	BLCA	TCGA	PVKTPTSS	DEG_SCF_FBW7_1	0.3056
p.P1986A	TCGA-TM-A84H	LGG	TCGA	PVKTPTSS	DEG_SCF_FBW7_1	0.2778
p.R2002K	DO219049	BLCA	ICGC	PVKTPTSS	DEG_SCF_FBW7_1	0.5833
p.N2003S	DO228483	BRCA	ICGC	PVKTPTSS	DEG_SCF_FBW7_1	0.1111
p.N2003S	DO229010	COCA	ICGC	PVKTPTSS	DEG_SCF_FBW7_1	0.1111
p.N2003S	DO229013	COCA	ICGC	PVKTPTSS	DEG_SCF_FBW7_1	0.1111
p.N2003S	DO229016	COCA	ICGC	PVKTPTSS	DEG_SCF_FBW7_1	0.1111
p.N2003S	DO228941	LICA	ICGC	PVKTPTSS	DEG_SCF_FBW7_1	0.1111
p.N2003S	DO229053	LICA	ICGC	PVKTPTSS	DEG_SCF_FBW7_1	0.1111
p.N2003S	DO52365	LUSC	ICGC	PVKTPTSS	DEG_SCF_FBW7_1	0.1111
p.A1994T	DO228945	LICA	ICGC	PVKTPTSS	DEG_SCF_FBW7_1	0.7139
p.K1983R	DO228945	LICA	ICGC	PVKTPTSS	DEG_SCF_FBW7_1	0.6389
p.S1995R	DO229036	LICA	ICGC	PVKTPTSS	DEG_SCF_FBW7_1	0.7427
p.S1995R	DO229045	LICA	ICGC	PVKTPTSS	DEG_SCF_FBW7_1	0.7427
p.P2000T	DO229035	LICA	ICGC	PVKTPTSS	DEG_SCF_FBW7_1	0.3056
p.R1999W	DO223286	UCEC	ICGC	PVKTPTSS	DEG_SCF_FBW7_1	0.2222
p.K1983T	DO52412	UCEC	ICGC	PVKTPTSS	DEG_SCF_FBW7_1	0.6389
p.K1997N	DO42713	UCEC	ICGC	PVKTPTSS	DEG_SCF_FBW7_1	0.2778
p.P2000L	DO42673	UCEC	ICGC	PVKTPTSS	DEG_SCF_FBW7_1	0.3056
p.G2004R	SIDM00608	Plasma Cell Myeloma	GDSC	PVKTPTSS	DEG_SCF_FBW7_1	0.0833
p.G2004R	SIDM00607	Glioblastoma	GDSC	PVKTPTSS	DEG_SCF_FBW7_1	0.0833
p.G2004R	SIDM00315	Glioblastoma	GDSC	PVKTPTSS	DEG_SCF_FBW7_1	0.0833
p.G2004R	SIDM00040	Gastric Carcinoma	GDSC	PVKTPTSS	DEG_SCF_FBW7_1	0.0833
p.G2004R	SIDM01439	Hepatocellular Carcinoma	GDSC	PVKTPTSS	DEG_SCF_FBW7_1	0.0833
p.G2004R	SIDM01448	Head and Neck Carcinoma	GDSC	PVKTPTSS	DEG_SCF_FBW7_1	0.0833
p.G2004R	SIDM01321	Pancreatic Carcinoma	GDSC	PVKTPTSS	DEG_SCF_FBW7_1	0.0833
p.G2004R	SIDM00164	Biliary Tract Carcinoma	GDSC	PVKTPTSS	DEG_SCF_FBW7_1	0.0833
p.C1981F	SIDM00973	Melanoma	GDSC	PVKTPTSS	DEG_SCF_FBW7_1	0.1389
p.C1981F	ACH-000827	Skin Cancer	CCLE	PVKTPTSS	DEG_SCF_FBW7_1	0.1389
p.C1981F	WM793B	skin	COSMIC	PVKTPTSS	DEG_SCF_FBW7_1	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PVKTPTSS

Degron related mutations and impact score

Drug responses associated with MKI67 mutations

All proteins holding degron of PVKTPTSS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P46013	Proliferation marker protein Ki-67	DEG_SCF_FBW7_1	1988:1995	PVKTPTSS	FBXW7	0.9362	More...