DegronMD

Uniprot ID: P46013

Source protein: Proliferation marker protein Ki-67

Source gene: MKI67

Class: DEG_SCF_FBW7_1

Location: 1108:1115

E3 ligase: FBXW7

DEGRON score: 0.9788

ASA_SCORE: 86.45

COIL: 0.8801

CONS_SCORE: 0.2849

DSS_SCORE: 0.6806

HELIX: 0.0408

FCONS_SCORE: 0.9873

RIG_SCORE: 0.636

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1112S	TCGA-2W-A8YY	CESC	TCGA	LFQTPGPS	DEG_SCF_FBW7_1	0.6752
p.T1120S	TCGA-BR-4361	STAD	TCGA	LFQTPGPS	DEG_SCF_FBW7_1	0.1944
p.P1114S	TCGA-D3-A2J7	SKCM	TCGA	LFQTPGPS	DEG_SCF_FBW7_1	0.5641
p.G1104A	TCGA-E8-A417	THCA	TCGA	LFQTPGPS	DEG_SCF_FBW7_1	0.2222
p.K1100R	DO7828	COAD	ICGC	LFQTPGPS	DEG_SCF_FBW7_1	0.1111
p.T1124M	DO44440	HNSC	ICGC	LFQTPGPS	DEG_SCF_FBW7_1	0.0833
p.D1106N	DO45492	LUSC	ICGC	LFQTPGPS	DEG_SCF_FBW7_1	0.7222
p.E1105Q	DO27540	LUSC	ICGC	LFQTPGPS	DEG_SCF_FBW7_1	0.25
p.P1103L	DO37406	SKCM	ICGC	LFQTPGPS	DEG_SCF_FBW7_1	0.1944
p.T1125P	DO52412	UCEC	ICGC	LFQTPGPS	DEG_SCF_FBW7_1	0.0556
p.F1114S	DO41758	UCEC	ICGC	LFQTPGPS	DEG_SCF_FBW7_1	0.7982
p.A1101T	COLO-679	skin	COSMIC	LFQTPGPS	DEG_SCF_FBW7_1	0.1389
p.T1124A	T98G	central_nervous_system	COSMIC	LFQTPGPS	DEG_SCF_FBW7_1	0.0833
p.T1124A	GDM-1	haematopoietic_and_lymphoid_tissue	COSMIC	LFQTPGPS	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P46013	Proliferation marker protein Ki-67	DEG_SCF_FBW7_1	1108:1115	LFQTPGPS	FBXW7	0.9788	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons