DegronMD

Uniprot ID: P46013

Source protein: Proliferation marker protein Ki-67

Source gene: MKI67

Class: DEG_SCF_FBW7_2

Location: 758:765

E3 ligase: FBXW7

DEGRON score: 0.9991

ASA_SCORE: 107.4125

COIL: 0.7506

CONS_SCORE: 0.5621

DSS_SCORE: 0.4023

HELIX: 0.1925

FCONS_SCORE: 1.2857

RIG_SCORE: 0.7844

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S771N	TCGA-A5-A2K5	UCEC	TCGA	MFKTPVKE	DEG_SCF_FBW7_2	0.1667
p.S771N	SIDM00493	Other Solid Cancers	GDSC	MFKTPVKE	DEG_SCF_FBW7_2	0.1667
p.S771N	NCI-H292	lung	COSMIC	MFKTPVKE	DEG_SCF_FBW7_2	0.1667
p.I775N	TCGA-DI-A1BU	UCEC	TCGA	MFKTPVKE	DEG_SCF_FBW7_2	0.0556
p.D751H	TCGA-DK-AA74	BLCA	TCGA	MFKTPVKE	DEG_SCF_FBW7_2	0.1389
p.P752S	DO223732	CESC	ICGC	MFKTPVKE	DEG_SCF_FBW7_2	0.1667
p.S771C	DO45318	LUAD	ICGC	MFKTPVKE	DEG_SCF_FBW7_2	0.1667
p.F749L	DO230961	LUSC	ICGC	MFKTPVKE	DEG_SCF_FBW7_2	0.5278
p.F749L	DO224594	LUSC	ICGC	MFKTPVKE	DEG_SCF_FBW7_2	0.5278
p.P772L	DO37406	SKCM	ICGC	MFKTPVKE	DEG_SCF_FBW7_2	0.1389
p.P773L	DO37452	SKCM	ICGC	MFKTPVKE	DEG_SCF_FBW7_2	0.1111
p.P754S	DO47695	SKCM	ICGC	MFKTPVKE	DEG_SCF_FBW7_2	0.2222
p.P772S	DO47601	SKCM	ICGC	MFKTPVKE	DEG_SCF_FBW7_2	0.1389
p.T760S	DO38887	STAD	ICGC	MFKTPVKE	DEG_SCF_FBW7_2	0.7116
p.C769R	DO40825	UCEC	ICGC	MFKTPVKE	DEG_SCF_FBW7_2	0.2222
p.A756V	SIDM01016	T-Lymphoblastic Leukemia	GDSC	MFKTPVKE	DEG_SCF_FBW7_2	0.2778
p.A756V	ACH-000995	Leukemia	CCLE	MFKTPVKE	DEG_SCF_FBW7_2	0.2778
p.P767L	SIDM00781	Colorectal Carcinoma	GDSC	MFKTPVKE	DEG_SCF_FBW7_2	0.2778
p.P767L	ACH-001199	Colon/Colorectal Cancer	CCLE	MFKTPVKE	DEG_SCF_FBW7_2	0.2778
p.P767L	SNU-C2B	large_intestine	COSMIC	MFKTPVKE	DEG_SCF_FBW7_2	0.2778
p.D751Y	SIDM00278	Esophageal Squamous Cell Carcinoma	GDSC	MFKTPVKE	DEG_SCF_FBW7_2	0.1389
p.D751Y	ACH-000305	Esophageal Cancer	CCLE	MFKTPVKE	DEG_SCF_FBW7_2	0.1389
p.D751Y	EC-GI-10	oesophagus	COSMIC	MFKTPVKE	DEG_SCF_FBW7_2	0.1389
p.E750G	SIDM00256	Neuroblastoma	GDSC	MFKTPVKE	DEG_SCF_FBW7_2	0.1111
p.E750G	ACH-002281	Neuroblastoma	CCLE	MFKTPVKE	DEG_SCF_FBW7_2	0.1111
p.E750G	NB14	autonomic_ganglia	COSMIC	MFKTPVKE	DEG_SCF_FBW7_2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P46013	Proliferation marker protein Ki-67	DEG_SCF_FBW7_2	758:765	MFKTPVKE	FBXW7	0.9991	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: MFKTPVKE

Degron related mutations and impact score

Drug responses associated with MKI67 mutations

All proteins holding degron of MFKTPVKE