DegronMD

Uniprot ID: P46013

Source protein: Proliferation marker protein Ki-67

Source gene: MKI67

Class: DEG_SCF_FBW7_1

Location: 1137:1143

E3 ligase: FBXW7

DEGRON score: 0.9956

ASA_SCORE: 87.8286

COIL: 0.9273

CONS_SCORE: 0.4059

DSS_SCORE: 0.6934

HELIX: 0.0226

FCONS_SCORE: 1.058

RIG_SCORE: 0.6488

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1131C	TCGA-55-A4DF	LUAD	TCGA	VDTPTST	DEG_SCF_FBW7_1	0.6111
p.P1140L	TCGA-BF-A3DL	SKCM	TCGA	VDTPTST	DEG_SCF_FBW7_1	0.7582
p.S1136T	TCGA-BG-A222	UCEC	TCGA	VDTPTST	DEG_SCF_FBW7_1	0.75
p.C1129R	TCGA-BK-A13B	UCEC	TCGA	VDTPTST	DEG_SCF_FBW7_1	0.1111
p.P1132S	TCGA-EB-A5UL	SKCM	TCGA	VDTPTST	DEG_SCF_FBW7_1	0.1944
p.P1133L	TCGA-ER-A19N	SKCM	TCGA	VDTPTST	DEG_SCF_FBW7_1	0.2222
p.P1132L	TCGA-FW-A3R5	SKCM	TCGA	VDTPTST	DEG_SCF_FBW7_1	0.1944
p.I1132M	DO51919	BLCA	ICGC	VDTPTST	DEG_SCF_FBW7_1	0.1944
p.K1131E	DO48566	BLCA	ICGC	VDTPTST	DEG_SCF_FBW7_1	0.6111
p.R1153K	DO44556	LGG	ICGC	VDTPTST	DEG_SCF_FBW7_1	0.5
p.P1149T	DO228985	LICA	ICGC	VDTPTST	DEG_SCF_FBW7_1	0.1667
p.P1138L	DO23108	LINC	ICGC	VDTPTST	DEG_SCF_FBW7_1	0.7582
p.P1138L	DO45041	LINC	ICGC	VDTPTST	DEG_SCF_FBW7_1	0.7582
p.D1139H	DO51232	SKCM	ICGC	VDTPTST	DEG_SCF_FBW7_1	0.7688
p.Q1137L	AU565	breast	COSMIC	VDTPTST	DEG_SCF_FBW7_1	0.7765

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P46013	Proliferation marker protein Ki-67	DEG_SCF_FBW7_1	1137:1143	VDTPTST	FBXW7	0.9956	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons