DegronMD

Uniprot ID: P46013

Source protein: Proliferation marker protein Ki-67

Source gene: MKI67

Class: DEG_SCF_FBW7_1

Location: 1473:1480

E3 ligase: FBXW7

DEGRON score: 0.9921

ASA_SCORE: 97.65

COIL: 0.8809

CONS_SCORE: 0.5322

DSS_SCORE: 0.4761

HELIX: 0.0411

FCONS_SCORE: 1.3582

RIG_SCORE: 0.7619

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1465Q	TCGA-39-5029	LUSC	TCGA	LFQTPVCT	DEG_SCF_FBW7_1	0.1111
p.D1466N	TCGA-85-8350	LUSC	TCGA	LFQTPVCT	DEG_SCF_FBW7_1	0.1389
p.F1474S	TCGA-B5-A1MR	UCEC	TCGA	LFQTPVCT	DEG_SCF_FBW7_1	0.6871
p.H1486Q	TCGA-DD-AAEI	LIHC	TCGA	LFQTPVCT	DEG_SCF_FBW7_1	0.1667
p.T1485P	TCGA-EO-A3AV	UCEC	TCGA	LFQTPVCT	DEG_SCF_FBW7_1	0.6389
p.T1484M	TCGA-F7-A624	HNSC	TCGA	LFQTPVCT	DEG_SCF_FBW7_1	0.2222
p.P1463L	TCGA-FW-A3R5	SKCM	TCGA	LFQTPVCT	DEG_SCF_FBW7_1	0.0556
p.A1466D	DO223732	CESC	ICGC	LFQTPVCT	DEG_SCF_FBW7_1	0.1389
p.T1488K	DO229028	LICA	ICGC	LFQTPVCT	DEG_SCF_FBW7_1	0.2222
p.L1469V	DO50922	LICA	ICGC	LFQTPVCT	DEG_SCF_FBW7_1	0.2222
p.R1476T	DO23759	LUAD	ICGC	LFQTPVCT	DEG_SCF_FBW7_1	0.7876
p.P1482L	DO45482	LUSC	ICGC	LFQTPVCT	DEG_SCF_FBW7_1	0.7222
p.L1478V	DO46428	OV	ICGC	LFQTPVCT	DEG_SCF_FBW7_1	0.6765
p.T1489P	DO41903	UCEC	ICGC	LFQTPVCT	DEG_SCF_FBW7_1	0.0833
p.T1484A	SIDM01057	Acute Myeloid Leukemia	GDSC	LFQTPVCT	DEG_SCF_FBW7_1	0.2222
p.T1484A	SIDM01171	Glioblastoma	GDSC	LFQTPVCT	DEG_SCF_FBW7_1	0.2222
p.T1484A	SIDM01594	Breast Carcinoma	GDSC	LFQTPVCT	DEG_SCF_FBW7_1	0.2222
p.T1484A	GDM-1	haematopoietic_and_lymphoid_tissue	COSMIC	LFQTPVCT	DEG_SCF_FBW7_1	0.2222
p.T1484A	T98G	central_nervous_system	COSMIC	LFQTPVCT	DEG_SCF_FBW7_1	0.2222
p.V1478I	ACH-000308	Ovarian Cancer	CCLE	LFQTPVCT	DEG_SCF_FBW7_1	0.5965
p.P1477L	ACH-001843	Bile Duct Cancer	CCLE	LFQTPVCT	DEG_SCF_FBW7_1	0.7582
p.T1488M	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	LFQTPVCT	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P46013	Proliferation marker protein Ki-67	DEG_SCF_FBW7_1	1473:1480	LFQTPVCT	FBXW7	0.9921	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons