DegronMD

Uniprot ID: P46013

Source protein: Proliferation marker protein Ki-67

Source gene: MKI67

Class: DEG_SCF_FBW7_1

Location: 841:848

E3 ligase: FBXW7

DEGRON score: 0.9887

ASA_SCORE: 101.2125

COIL: 0.9066

CONS_SCORE: 0.4993

DSS_SCORE: 0.584

HELIX: 0.0319

FCONS_SCORE: 1.3303

RIG_SCORE: 0.6958

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V841I	TCGA-AP-A0LM	UCEC	TCGA	VAKTPRNT	DEG_SCF_FBW7_1	0.5965
p.S853F	TCGA-AP-A1DV	UCEC	TCGA	VAKTPRNT	DEG_SCF_FBW7_1	0.6389
p.K857Q	TCGA-AX-A05Z	UCEC	TCGA	VAKTPRNT	DEG_SCF_FBW7_1	0.5278
p.R836T	TCGA-BH-A0BP	BRCA	TCGA	VAKTPRNT	DEG_SCF_FBW7_1	0.1944
p.P854T	DO44083	BLCA	ICGC	VAKTPRNT	DEG_SCF_FBW7_1	0.1667
p.L851V	DO231223	LAML	ICGC	VAKTPRNT	DEG_SCF_FBW7_1	0.25
p.A858T	DO22143	LGG	ICGC	VAKTPRNT	DEG_SCF_FBW7_1	0.5
p.G846V	DO231114	LUSC	ICGC	VAKTPRNT	DEG_SCF_FBW7_1	0.7532
p.G842E	DO220859	MELA	ICGC	VAKTPRNT	DEG_SCF_FBW7_1	0.7199
p.R849T	DO50684	ORCA	ICGC	VAKTPRNT	DEG_SCF_FBW7_1	0.75
p.D839H	DO219503	SKCM	ICGC	VAKTPRNT	DEG_SCF_FBW7_1	0.2778
p.K837E	DO43466	UCEC	ICGC	VAKTPRNT	DEG_SCF_FBW7_1	0.2222
p.T853S	DO42105	UCEC	ICGC	VAKTPRNT	DEG_SCF_FBW7_1	0.6389
p.G832E	DO52412	UCEC	ICGC	VAKTPRNT	DEG_SCF_FBW7_1	0.0833
p.R832Q	SIDM00523	Small Cell Lung Carcinoma	GDSC	VAKTPRNT	DEG_SCF_FBW7_1	0.0833
p.R832Q	ACH-000698	Lung Cancer	CCLE	VAKTPRNT	DEG_SCF_FBW7_1	0.0833
p.R832Q	DMS-53	lung	COSMIC	VAKTPRNT	DEG_SCF_FBW7_1	0.0833
p.K850E	SIDM00989	Bladder Carcinoma	GDSC	VAKTPRNT	DEG_SCF_FBW7_1	0.7222
p.K850E	ACH-000802	Bladder Cancer	CCLE	VAKTPRNT	DEG_SCF_FBW7_1	0.7222
p.K850E	BFTC-905	urinary_tract	COSMIC	VAKTPRNT	DEG_SCF_FBW7_1	0.7222
p.R831T	SIDM00989	Bladder Carcinoma	GDSC	VAKTPRNT	DEG_SCF_FBW7_1	0.0556
p.R831T	ACH-000802	Bladder Cancer	CCLE	VAKTPRNT	DEG_SCF_FBW7_1	0.0556
p.R831T	BFTC-905	urinary_tract	COSMIC	VAKTPRNT	DEG_SCF_FBW7_1	0.0556
p.S853Y	SIDM00118	Colorectal Carcinoma	GDSC	VAKTPRNT	DEG_SCF_FBW7_1	0.6389
p.S853Y	ACH-001081	Colon/Colorectal Cancer	CCLE	VAKTPRNT	DEG_SCF_FBW7_1	0.6389
p.S853Y	HCC2998	large_intestine	COSMIC	VAKTPRNT	DEG_SCF_FBW7_1	0.6389
p.A841T	NCI-H2342	lung	COSMIC	VAKTPRNT	DEG_SCF_FBW7_1	0.7139

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P46013	Proliferation marker protein Ki-67	DEG_SCF_FBW7_1	841:848	VAKTPRNT	FBXW7	0.9887	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VAKTPRNT

Degron related mutations and impact score

Drug responses associated with MKI67 mutations

All proteins holding degron of VAKTPRNT