DegronMD

Uniprot ID: P46013

Source protein: Proliferation marker protein Ki-67

Source gene: MKI67

Class: DEG_SCF_FBW7_1

Location: 2111:2117

E3 ligase: FBXW7

DEGRON score: 0.9397

ASA_SCORE: 93.3714

COIL: 0.9317

CONS_SCORE: 0.3801

DSS_SCORE: 0.8405

HELIX: 0.0213

FCONS_SCORE: 0.9924

RIG_SCORE: 0.6179

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A2102V	TCGA-68-7755	LUSC	TCGA	MDTPTST	DEG_SCF_FBW7_1	0.0833
p.A2102S	TCGA-77-A5GH	LUSC	TCGA	MDTPTST	DEG_SCF_FBW7_1	0.0833
p.R2120W	TCGA-AP-A1DV	UCEC	TCGA	MDTPTST	DEG_SCF_FBW7_1	0.25
p.R2120W	SIDM02039	Colorectal Carcinoma	GDSC	MDTPTST	DEG_SCF_FBW7_1	0.25
p.M2111V	TCGA-CG-5728	STAD	TCGA	MDTPTST	DEG_SCF_FBW7_1	0.6097
p.P2108S	TCGA-D1-A103	UCEC	TCGA	MDTPTST	DEG_SCF_FBW7_1	0.25
p.P2106S	TCGA-EE-A3JD	SKCM	TCGA	MDTPTST	DEG_SCF_FBW7_1	0.1944
p.T2114P	DO230326	COCA	ICGC	MDTPTST	DEG_SCF_FBW7_1	0.7031
p.E2101K	DO233146	GACA	ICGC	MDTPTST	DEG_SCF_FBW7_1	0.0556
p.E2101K	DO42568	UCEC	ICGC	MDTPTST	DEG_SCF_FBW7_1	0.0556
p.F2112L	DO219080	HNSC	ICGC	MDTPTST	DEG_SCF_FBW7_1	0.6981
p.R2121K	DO228349	MALY	ICGC	MDTPTST	DEG_SCF_FBW7_1	0.2222
p.R2121K	NAMALWA	haematopoietic_and_lymphoid_tissue	COSMIC	MDTPTST	DEG_SCF_FBW7_1	0.2222
p.S2103F	DO222644	MELA	ICGC	MDTPTST	DEG_SCF_FBW7_1	0.1111
p.S2103F	DO47525	SKCM	ICGC	MDTPTST	DEG_SCF_FBW7_1	0.1111
p.S2103F	DO219466	SKCM	ICGC	MDTPTST	DEG_SCF_FBW7_1	0.1111
p.K2113E	DO50076	UCEC	ICGC	MDTPTST	DEG_SCF_FBW7_1	0.7022
p.T2117I	SIDM00330	Neuroblastoma	GDSC	MDTPTST	DEG_SCF_FBW7_1	0.7078
p.T2117I	ACH-001355	Neuroblastoma	CCLE	MDTPTST	DEG_SCF_FBW7_1	0.7078
p.T2117I	LAN-6	autonomic_ganglia	COSMIC	MDTPTST	DEG_SCF_FBW7_1	0.7078
p.P2107L	SIDM01761	Rhabdomyosarcoma	GDSC	MDTPTST	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P46013	Proliferation marker protein Ki-67	DEG_SCF_FBW7_1	2111:2117	MDTPTST	FBXW7	0.9397	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons