DegronMD

Uniprot ID: P46013

Source protein: Proliferation marker protein Ki-67

Source gene: MKI67

Class: DEG_SCF_FBW7_1

Location: 1500:1507

E3 ligase: FBXW7

DEGRON score: 0.9897

ASA_SCORE: 90.5875

COIL: 0.9383

CONS_SCORE: 0.3182

DSS_SCORE: 0.7097

HELIX: 0.0199

FCONS_SCORE: 1.1219

RIG_SCORE: 0.6218

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D1499H	TCGA-3N-A9WB	SKCM	TCGA	PVDTPTSS	DEG_SCF_FBW7_1	0.3056
p.K1491E	TCGA-DK-A6AW	BLCA	TCGA	PVDTPTSS	DEG_SCF_FBW7_1	0.1944
p.R1513K	TCGA-P5-A5F1	LGG	TCGA	PVDTPTSS	DEG_SCF_FBW7_1	0.1667
p.I1492M	TCGA-XF-A9SZ	BLCA	TCGA	PVDTPTSS	DEG_SCF_FBW7_1	0.1111
p.R1516Q	DO228483	BRCA	ICGC	PVDTPTSS	DEG_SCF_FBW7_1	0.0833
p.R1516Q	DO229010	COCA	ICGC	PVDTPTSS	DEG_SCF_FBW7_1	0.0833
p.R1516Q	DO229013	COCA	ICGC	PVDTPTSS	DEG_SCF_FBW7_1	0.0833
p.R1516Q	DO229016	COCA	ICGC	PVDTPTSS	DEG_SCF_FBW7_1	0.0833
p.R1516Q	DO229480	LAML	ICGC	PVDTPTSS	DEG_SCF_FBW7_1	0.0833
p.R1516Q	DO228941	LICA	ICGC	PVDTPTSS	DEG_SCF_FBW7_1	0.0833
p.R1516Q	DO230536	LUSC	ICGC	PVDTPTSS	DEG_SCF_FBW7_1	0.0833
p.R1516Q	DO231064	LUSC	ICGC	PVDTPTSS	DEG_SCF_FBW7_1	0.0833
p.R1516Q	DO231075	LUSC	ICGC	PVDTPTSS	DEG_SCF_FBW7_1	0.0833
p.P1517L	DO229010	COCA	ICGC	PVDTPTSS	DEG_SCF_FBW7_1	0.5
p.P1517L	DO229016	COCA	ICGC	PVDTPTSS	DEG_SCF_FBW7_1	0.5
p.P1517L	DO228941	LICA	ICGC	PVDTPTSS	DEG_SCF_FBW7_1	0.5
p.P1517L	DO231075	LUSC	ICGC	PVDTPTSS	DEG_SCF_FBW7_1	0.5
p.A1507E	DO229029	LICA	ICGC	PVDTPTSS	DEG_SCF_FBW7_1	0.7701
p.T1494N	DO229027	LICA	ICGC	PVDTPTSS	DEG_SCF_FBW7_1	0.1667
p.P1510Q	DO229037	LICA	ICGC	PVDTPTSS	DEG_SCF_FBW7_1	0.25
p.K1500I	DO230942	LUSC	ICGC	PVDTPTSS	DEG_SCF_FBW7_1	0.7531
p.K1500I	DO224589	LUSC	ICGC	PVDTPTSS	DEG_SCF_FBW7_1	0.7531
p.D1508N	DO30280	OV	ICGC	PVDTPTSS	DEG_SCF_FBW7_1	0.75
p.E1491D	DO232224	PBCA	ICGC	PVDTPTSS	DEG_SCF_FBW7_1	0.1944
p.P1502L	DO38619	STAD	ICGC	PVDTPTSS	DEG_SCF_FBW7_1	0.7582
p.P1502L	451Lu	skin	COSMIC	PVDTPTSS	DEG_SCF_FBW7_1	0.7582
p.T1511A	DO52402	UCEC	ICGC	PVDTPTSS	DEG_SCF_FBW7_1	0.6667
p.P1504L	SIDM01945	Colorectal Carcinoma	GDSC	PVDTPTSS	DEG_SCF_FBW7_1	0.7582
p.A1493D	SIDM00690	Head and Neck Carcinoma	GDSC	PVDTPTSS	DEG_SCF_FBW7_1	0.1389
p.A1493D	SIDM00836	Colorectal Carcinoma	GDSC	PVDTPTSS	DEG_SCF_FBW7_1	0.1389
p.A1493D	SIDM01318	Hepatocellular Carcinoma	GDSC	PVDTPTSS	DEG_SCF_FBW7_1	0.1389
p.Q1497L	SIDM00898	Breast Carcinoma	GDSC	PVDTPTSS	DEG_SCF_FBW7_1	0.25
p.Q1497L	ACH-000248	Breast Cancer	CCLE	PVDTPTSS	DEG_SCF_FBW7_1	0.25
p.Q1497L	AU565	breast	COSMIC	PVDTPTSS	DEG_SCF_FBW7_1	0.25
p.P1498S	SIDM00793	Burkitt's Lymphoma	GDSC	PVDTPTSS	DEG_SCF_FBW7_1	0.2778
p.P1498S	ACH-002236	Lymphoma	CCLE	PVDTPTSS	DEG_SCF_FBW7_1	0.2778
p.T1509A	OACp4C	oesophagus	COSMIC	PVDTPTSS	DEG_SCF_FBW7_1	0.2778
p.T1509A	NCI-H187	lung	COSMIC	PVDTPTSS	DEG_SCF_FBW7_1	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PVDTPTSS

Degron related mutations and impact score

Drug responses associated with MKI67 mutations

All proteins holding degron of PVDTPTSS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P46013	Proliferation marker protein Ki-67	DEG_SCF_FBW7_1	1500:1507	PVDTPTSS	FBXW7	0.9897	More...