DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
PRKTPVAS
Uniprot ID:
P46013
Source protein:
Proliferation marker protein Ki-67
Source gene:
MKI67
Class:
DEG_SCF_FBW7_1
Location:
585:592
E3 ligase:
FBXW7
DEGRON score:
0.9347
ASA_SCORE:
104.75
COIL:
0.9365
CONS_SCORE:
0.2742
DSS_SCORE:
0.7573
HELIX:
0.0408
FCONS_SCORE:
0.9485
RIG_SCORE:
0.6287
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R596H
TCGA-AJ-A3OJ
UCEC
TCGA
PRKTPVAS
DEG_SCF_FBW7_1
0.2222
p.L576S
TCGA-AP-A1E0
UCEC
TCGA
PRKTPVAS
DEG_SCF_FBW7_1
0.0833
p.R596C
TCGA-BS-A0UF
UCEC
TCGA
PRKTPVAS
DEG_SCF_FBW7_1
0.2222
p.R596S
TCGA-D3-A2JP
SKCM
TCGA
PRKTPVAS
DEG_SCF_FBW7_1
0.2222
p.A591G
TCGA-IS-A3K7
SARC
TCGA
PRKTPVAS
DEG_SCF_FBW7_1
0.6429
p.E580Q
DO51925
BLCA
ICGC
PRKTPVAS
DEG_SCF_FBW7_1
0.1944
p.M588I
DO49974
CESC
ICGC
PRKTPVAS
DEG_SCF_FBW7_1
0.7618
p.D582N
DO222459
ESCA
ICGC
PRKTPVAS
DEG_SCF_FBW7_1
0.25
p.P600Q
DO229029
LICA
ICGC
PRKTPVAS
DEG_SCF_FBW7_1
0.2222
p.E583K
DO229050
LICA
ICGC
PRKTPVAS
DEG_SCF_FBW7_1
0.2778
p.D582Y
DO219317
PRAD
ICGC
PRKTPVAS
DEG_SCF_FBW7_1
0.25
p.N575T
DO41752
UCEC
ICGC
PRKTPVAS
DEG_SCF_FBW7_1
0.5
p.K584N
DO41572
UCEC
ICGC
PRKTPVAS
DEG_SCF_FBW7_1
0.75
p.K597N
NCI-H1915
lung
COSMIC
PRKTPVAS
DEG_SCF_FBW7_1
0.1944
p.N581T
FADU
upper_aerodigestive_tract
COSMIC
PRKTPVAS
DEG_SCF_FBW7_1
0.2222
Drug responses associated with MKI67 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PRKTPVAS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P46013
Proliferation marker protein Ki-67
DEG_SCF_FBW7_1
585:592
PRKTPVAS
FBXW7
0.9347
More...