DegronMD

Uniprot ID: P46013

Source protein: Proliferation marker protein Ki-67

Source gene: MKI67

Class: DEG_SCF_FBW7_1

Location: 585:592

E3 ligase: FBXW7

DEGRON score: 0.9347

ASA_SCORE: 104.75

COIL: 0.9365

CONS_SCORE: 0.2742

DSS_SCORE: 0.7573

HELIX: 0.0408

FCONS_SCORE: 0.9485

RIG_SCORE: 0.6287

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M588I	DO49974	CESC	ICGC	PRKTPVAS	DEG_SCF_FBW7_1	0.7618
p.K584N	DO41572	UCEC	ICGC	PRKTPVAS	DEG_SCF_FBW7_1	0.75
p.A591G	TCGA-IS-A3K7	SARC	TCGA	PRKTPVAS	DEG_SCF_FBW7_1	0.6429
p.N575T	DO41752	UCEC	ICGC	PRKTPVAS	DEG_SCF_FBW7_1	0.5
p.E583K	DO229050	LICA	ICGC	PRKTPVAS	DEG_SCF_FBW7_1	0.2778
p.D582N	DO222459	ESCA	ICGC	PRKTPVAS	DEG_SCF_FBW7_1	0.25
p.D582Y	DO219317	PRAD	ICGC	PRKTPVAS	DEG_SCF_FBW7_1	0.25
p.R596H	TCGA-AJ-A3OJ	UCEC	TCGA	PRKTPVAS	DEG_SCF_FBW7_1	0.2222
p.R596C	TCGA-BS-A0UF	UCEC	TCGA	PRKTPVAS	DEG_SCF_FBW7_1	0.2222
p.R596S	TCGA-D3-A2JP	SKCM	TCGA	PRKTPVAS	DEG_SCF_FBW7_1	0.2222
p.P600Q	DO229029	LICA	ICGC	PRKTPVAS	DEG_SCF_FBW7_1	0.2222
p.N581T	FADU	upper_aerodigestive_tract	COSMIC	PRKTPVAS	DEG_SCF_FBW7_1	0.2222
p.E580Q	DO51925	BLCA	ICGC	PRKTPVAS	DEG_SCF_FBW7_1	0.1944
p.K597N	NCI-H1915	lung	COSMIC	PRKTPVAS	DEG_SCF_FBW7_1	0.1944
p.L576S	TCGA-AP-A1E0	UCEC	TCGA	PRKTPVAS	DEG_SCF_FBW7_1	0.0833

Showing 1 to 15 of 15 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P46013	Proliferation marker protein Ki-67	DEG_SCF_FBW7_1	585:592	PRKTPVAS	FBXW7	0.9347	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons