DegronMD - Q9Y6A5(TACC3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S33L	TCGA-A5-A0G2	UCEC	TCGA	QKENV	DEG_APCC_KENBOX_2	40:44	Mutation rewiring degron network	0.1389
p.S33L	DO41235	UCEC	ICGC	QKENV	DEG_APCC_KENBOX_2	40:44	Mutation rewiring degron network	0.1389
p.S210F	TCGA-AP-A059	UCEC	TCGA	VTPASE	DEG_SCF_FBW7_2	195:200	Mutation rewiring degron network	0.0556
p.S210F	TCGA-D9-A3Z1	SKCM	TCGA	VTPASE	DEG_SCF_FBW7_2	195:200	Mutation rewiring degron network	0.0556
p.S210F	DO38105	SKCM	ICGC	VTPASE	DEG_SCF_FBW7_2	195:200	Mutation rewiring degron network	0.0556
p.S210F	DO41361	UCEC	ICGC	VTPASE	DEG_SCF_FBW7_2	195:200	Mutation rewiring degron network	0.0556
p.V44L	TCGA-B7-5816	STAD	TCGA	QKENV	DEG_APCC_KENBOX_2	40:44	Mutation altering degron motif	0.5654
p.V44L	DO38599	STAD	ICGC	QKENV	DEG_APCC_KENBOX_2	40:44	Mutation altering degron motif	0.5654
p.R37C	TCGA-CM-6162	COAD	TCGA	QKENV	DEG_APCC_KENBOX_2	40:44	Mutation rewiring degron network	0.25
p.R37C	DO8479	COAD	ICGC	QKENV	DEG_APCC_KENBOX_2	40:44	Mutation rewiring degron network	0.25
p.R37C	SIDM00451	T-Lymphoblastic Leukemia	GDSC	QKENV	DEG_APCC_KENBOX_2	40:44	Mutation rewiring degron network	0.25
p.R37C	PF-382	haematopoietic and lymphoid tissue	COSMIC	QKENV	DEG_APCC_KENBOX_2	40:44	Mutation rewiring degron network	0.25
p.L36I	TCGA-EO-A3AY	UCEC	TCGA	QKENV	DEG_APCC_KENBOX_2	40:44	Mutation rewiring degron network	0.2222
p.L36I	DO46853	RECA	ICGC	QKENV	DEG_APCC_KENBOX_2	40:44	Mutation rewiring degron network	0.2222
p.L36I	DO43202	UCEC	ICGC	QKENV	DEG_APCC_KENBOX_2	40:44	Mutation rewiring degron network	0.2222
p.S39P	DO7102	CLLE	ICGC	QKENV	DEG_APCC_KENBOX_2	40:44	Mutation blocking phosphorylation signal	0.75
p.G31R	DO233156	GACA	ICGC	QKENV	DEG_APCC_KENBOX_2	40:44	Mutation rewiring degron network	0.0833
p.M53V	DO23551	LIRI	ICGC	QKENV	DEG_APCC_KENBOX_2	40:44	Mutation rewiring degron network	0.0833
p.S199F	SIDM01951	Colorectal Carcinoma	GDSC	VTPASE	DEG_SCF_FBW7_2	195:200	Mutation altering degron motif	0.6871
p.R37G	SIDM00664	Pancreatic Carcinoma	GDSC	QKENV	DEG_APCC_KENBOX_2	40:44	Mutation rewiring degron network	0.25
p.R37G	ACH-000178	Pancreatic Cancer	CCLE	QKENV	DEG_APCC_KENBOX_2	40:44	Mutation rewiring degron network	0.25
p.R37G	Hs766T	pancreas	COSMIC	QKENV	DEG_APCC_KENBOX_2	40:44	Mutation rewiring degron network	0.25
p.R193K	SIDM00367	Small Cell Lung Carcinoma	GDSC	VTPASE	DEG_SCF_FBW7_2	195:200	Mutation rewiring degron network	0.2778
p.R193K	SIDM01574	Plasma Cell Myeloma	GDSC	VTPASE	DEG_SCF_FBW7_2	195:200	Mutation rewiring degron network	0.2778
p.R193K	ACH-000588	Myeloma	CCLE	VTPASE	DEG_SCF_FBW7_2	195:200	Mutation rewiring degron network	0.2778
p.R193K	ACH-002197	Lung Cancer	CCLE	VTPASE	DEG_SCF_FBW7_2	195:200	Mutation rewiring degron network	0.2778
p.S190F	SIDM00795	Melanoma	GDSC	VTPASE	DEG_SCF_FBW7_2	195:200	Mutation rewiring degron network	0.1944
p.S190F	ACH-000219	Skin Cancer	CCLE	VTPASE	DEG_SCF_FBW7_2	195:200	Mutation rewiring degron network	0.1944
p.S190F	ACH-002001	Skin Cancer	CCLE	VTPASE	DEG_SCF_FBW7_2	195:200	Mutation rewiring degron network	0.1944
p.S190F	ACH-002002	Skin Cancer	CCLE	VTPASE	DEG_SCF_FBW7_2	195:200	Mutation rewiring degron network	0.1944
p.S190F	ACH-002003	Skin Cancer	CCLE	VTPASE	DEG_SCF_FBW7_2	195:200	Mutation rewiring degron network	0.1944
p.S190F	A375	skin	COSMIC	VTPASE	DEG_SCF_FBW7_2	195:200	Mutation rewiring degron network	0.1944
p.D192N	SIDM00442	Thyroid Gland Carcinoma	GDSC	VTPASE	DEG_SCF_FBW7_2	195:200	Mutation rewiring degron network	0.25
p.D192N	ACH-000058	Thyroid Cancer	CCLE	VTPASE	DEG_SCF_FBW7_2	195:200	Mutation rewiring degron network	0.25
p.D192N	ML-1	thyroid	COSMIC	VTPASE	DEG_SCF_FBW7_2	195:200	Mutation rewiring degron network	0.25
p.V195M	SIDM01660	Kidney Carcinoma	GDSC	VTPASE	DEG_SCF_FBW7_2	195:200	Mutation altering degron motif	0.6097
p.V195M	ACH-000709	Kidney Cancer	CCLE	VTPASE	DEG_SCF_FBW7_2	195:200	Mutation altering degron motif	0.6097
p.V195M	ACH-001184	Sarcoma	CCLE	VTPASE	DEG_SCF_FBW7_2	195:200	Mutation altering degron motif	0.6097
p.E200K	ACH-001283	Bone Cancer	CCLE	VTPASE	DEG_SCF_FBW7_2	195:200	Mutation altering degron motif	0.7022

Kaplan plot for TACC3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TACC3

UniProt ID: Q9Y6A5

Entrez ID: 10460

Protein name: Transforming acidic coiled-coil-containing protein 3 (ERIC-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TACC3 in